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Vitamin D and mineral ion homeostasis: Endocrine dysregulation in chronic diseases
Vitamin D is a steroidal hormone required to maintain normal blood levels of various mineral ions needed for a wide range of cellular functions, including skeletal mineralization and muscle contraction. Vitamin D is a crucial part of the endocrine system that controls whole-body calcium and phosphate homeostasis. Optimal mineral ion balance is requisite for the physiological functions of cells and organs. Vitamin D enables the absorption of various minerals, including calcium, phosphorus, magnesium, copper, zinc, iron, and selenium. While certain minerals, including magnesium and zinc, act as cofactors to activate vitamin D and be functional. Similarly, calcium and phosphorus are involved in vitamin D-mediated signaling events. Vitamin D also facilitates the uptake of toxic elements, including lead, arsenic, aluminum, cobalt, and strontium.
Depression and Diabetes
In recent years, there has been a growing awareness of the multiple interrelationships between depression and various physical diseases. The WPA is providing an update of currently available evidence on these interrelationships by the publication of three books, dealing with the comorbidity of depression with diabetes, heart disease and cancer. Depression is a frequent and serious comorbid condition in diabetes, which adversely affects quality of life and the long-term prognosis. Co-occurrent depression presents peculiar clinical challenges, making both conditions harder to manage. Depression and Diabetes is the first book devoted to the interaction between these common disorders. World lead...
Omega-3 Fatty Acids in Brain and Neurological Health
Research has clearly established a link between omega-3 fatty acids and general health, particularly cardiovascular health. Omega-3 Fatty Acids in Brain and Neurological Health is the first book to focus exclusively on the role of omega-3 fatty acids on general brain health. The articles in this collection illustrate omega-3 fatty acids' importance in longevity, cognitive impairment, and structure and function of the brain's neurons. Research has established links between omega-3 fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis. This book encompasses some of the most recent research, including the role of omega-3 fatty acid supplements on hipp...
Automated Scheduling and Planning
Solving scheduling problems has long presented a challenge for computer scientists and operations researchers. The field continues to expand as researchers and practitioners examine ever more challenging problems and develop automated methods capable of solving them. This book provides 11 case studies in automated scheduling, submitted by leading researchers from across the world. Each case study examines a challenging real-world problem by analysing the problem in detail before investigating how the problem may be solved using state of the art techniques.The areas covered include aircraft scheduling, microprocessor instruction scheduling, sports fixture scheduling, exam scheduling, personnel scheduling and production scheduling. Problem solving methodologies covered include exact as well as (meta)heuristic approaches, such as local search techniques, linear programming, genetic algorithms and ant colony optimisation.The field of automated scheduling has the potential to impact many aspects of our lives and work; this book highlights contributions to the field by world class researchers.
Weight Gain During Pregnancy
As women of childbearing age have become heavier, the trade-off between maternal and child health created by variation in gestational weight gain has become more difficult to reconcile. Weight Gain During Pregnancy responds to the need for a reexamination of the 1990 Institute of Medicine guidelines for weight gain during pregnancy. It builds on the conceptual framework that underscored the 1990 weight gain guidelines and addresses the need to update them through a comprehensive review of the literature and independent analyses of existing databases. The book explores relationships between weight gain during pregnancy and a variety of factors (e.g., the mother's weight and height before preg...
