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"This story has been pieced together from a myriad of fossil finds, prehistoric cave paintings, discarded stone tools, and traces of ancient genetic material. In this account, Robin McKie, Science Editor of The Observer, unravels the saga of how these discoveries form a picture of our ancestors' lives. It is a scientific detective story full of paleontologist-detectives whose intellect and foibles add to the adventure. The story arrives at a revelation of how our world became dominated by a single primate species: Homo sapiens."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
This book provides a comprehensive, state-of-the art review of hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD). The book reviews new data about risk prediction for severe SCD, outlines the unique challenges of HSCT for patients with SCD, profiles the supportive care guidelines for patients who are undergoing HSCT, highlights our current understanding of the best transfusion support for SCD patients prior to, during and after HSCT, and provides new perspectives about the ethics of HSCT for pediatric patients with SCD. Published in the last few years, several landmark phase III trials that utilize matched unrelated and haploidentical donors for HSCT in SCD patients are also placed in context with respect to current management. Written by experts in the field, Sickle Cell Disease and Hematopoietic Stem Cell Transplantation is a valuable resource for physicians and researchers dealing with and interested in this challenging, yet exciting, curative therapy for sickle cell disease, that will help guide patient management and stimulate investigative efforts.
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