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Molecular Basis of Chronic Myeloproliferative Disorders
Since the first description of Philadelphia chromosome-negative chronic myeloproliferative disorders more than 100 years ago, the diagnosis and therapy of these conditions have been based primarily on clinical experience and judgement. Until recently very little was known about the molecular basis of these diseases. In order to spark research in this area basic scientists and clinicians from various parts of the world have contributed to this volume, the first of its kind to put together the current knowledge. The book deals with the new WHO classification of these disorders, novel aspects of diagnostic pathology, the search for disease-relevant genes utilizing molecular biology and proteomic techniques, the description of the roles of PVR-1 and VHL genes for polycythemias and the discovery of the gene mutation responsible for the idiopathic hypereosinophilic syndrome. A chapter on anagrelide, an important novel drug for the treatment of primary thrombocythemia, is included.
Myeloproliferative Disorders
With the recent discovery of JAK2 mutations in myeloproliferative disorders, medical science has taken a revolutionary stride forward toward understanding the pathogenesis of these diseases. This new advancement translates not only to a more rapid and reliable diagnosis, but also allows groundbreaking research into the development of new therapeuti
Advanced Coating Materials
Provides a comprehensive, yet practical source of reference, and excellent foundation for comparing the properties and performance of coatings and selecting the most suitable materials based on specific service needs and environmental factors. Coating technology has developed significant techniques for protecting existing infrastructure from corrosion and erosion, maintaining and enhancing the performance of equipment, and provided novel functions such as smart coatings greatly benefiting the medical device, energy, automotive and construction industries. The mechanisms, usage, and manipulation of cutting-edge coating methods are the focus of this book. Not only are the working mechanisms of...
Mineralogy and Geochemistry of Gems
Gems have been used in the manufacture of jewellery and as ornaments since antiquity. Considering gems, recent statistics have shown that about 15 billion Euros are annually at stake. Nowadays, gemmology, i.e., the study of gem materials, is one of the most expanding fields in the earth sciences, positioned between academia and industry. As an applied science, in gemmology, the instruments used should be non- or microdestructive, and their cost should be reasonable both in terms of equipment and time consumption. Gemmology can also be used contribute to the development of pure science and in some cases, destructive techniques may have to be used. Taking into account the fact that gems are al...
Frontiers in Anti-Cancer Drug Discovery
Frontiers in Anti-Cancer Drug Discovery is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery, including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The Ebook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. The Ebook series is essential reading for all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.
Living Traditions
How has the Christian movement grown and changed in the last five hundred years? From Luther to Tillich and the Virgin Mary, from Protestant initiatives and Catholic dialogues, from Charles Taylor to progressive Christianity, this book runs the gamut. The urgency of ecology, the sacramentality of foot-washing, the complexities of biblical interpretation, the theology of the cross, and the ongoing work of reformation are all under the microscope. A distinctively ecumenical project, this book presents a variety of perspectives on these pressing questions, drawing together authors from the Anglican, Baptist, Lutheran, Roman Catholic, United Church of Canada traditions, and more. Each contributor provides unique insights into Christianity's ongoing processes of re-forming as contexts and circumstances change. Readers will find resonances of the familiar interwoven with new research about the project of ecumenical Christianity.
