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Soccer
Written with both coaches and players in mind, this volume offers a comprehensive overview of the skills and knowledge a goalkeeper needs to succeed. Goalkeeper Training is filled with proven training exercises accompanied by easy-to-follow illustrations that will help players and coaches of all levels improve their technique and learn new skills.
Small Molecules in Oncology
Extensive research into the molecular mechanisms of cancer disease has heralded a new age of targeted therapy. In malignant cells, key proteins that are crucial to tumor growth and survival are now being targeted directly with rationally designed inhibitors. Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention. This textbook, written by acknowledged experts, provides a broad overview of the small molecules currently used for the treatment of malignant diseases and discusses interesting novel compounds that are in the process of clinical development to combat cancer.
Hitler's Foreign Workers
An account of the millions of foreign workers imported into Germany during the Second World War.
Epigenetics and Disease
Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.
DNA Methylation
DNA Methylation: Approaches, Methods and Applications describes the relation DNA methylation has to gene silencing in disease, and explores its promising role in treating cancer. Written by leaders in the field, this exceptional compilation of articles outlines the best techniques to use when addressing questions concerning the cytosine methylation
An Ecumenical Odyssey
No less than two decades were needed for the composition of the ecumenical convergence document The Church: Towards a Common Vision (TCTCV) which was published by the World Council of Churches in 2013. The document was intended to reflect a common vision of churches and ecumenical stakeholders on a myriad of ecclesiological themes. The book investigates whether the convergence document TCTCV delivers on its promises. The book focuses on the formation and the reception of TCTCV along with the two draft versions, The Nature and Purpose of the Church (1998) and The Nature and Mission of the Church (2005) and uncovers whether the responses by the churches to TCTCV hold an affirmation of the convergences registered in the document. Furthermore, it seeks to establish whether the responses point towards a "common vision" concerning various ecclesiological themes that are still contested by the churches today. The book also explores whether the responses to TCTCV reveal an advancement in the conversation surrounding several debated issues, and examines to what extent the churches are willing to creatively engage with the ecclesial other.
German Protestants Remember the Holocaust
Focusing on the 1980s-90s, examines how Protestants in Germany interpret their self-understanding as part of the community which is defined by its connection to the Nazi past. Analyzes representations of the Holocaust and of the Christian-Jewish relationship in three German Protestant theological texts: the 1980 statement of the Rhineland synod of the Evangelical Church "Zur Erneuerung des Verhältnisses von Christen und Juden"; Marquardt's theological text "Von Elend und Heimsuchung der Theologie: Prolegomena zur Dogmatik" (1992); and Britta Jüngst's dissertation "Auf der Seite des Todes das Leben" (1996). The analysis of these texts is informed by the development of narratives of collecti...
Pathways to the Public Square
This volume represents the proceedings of the 2003 meeting of the International Academy of Practical Theology, which was held in Manchester (UK) on the theme of 'public theology'. Featuring over twenty papers from some of the world's leading practical theologians, 'Pathways to the Public Square' offers a wide variety of perspectives on the relationship between theology and politics, education, law, culture and economics. They include subjects as diverse as the role of religion in the constitution of the European Union, theological themes in popular music, Roman Catholic-Muslim dialogue in the U.S.A., and the spirituality of the public realm. This book will be of interest to theological educators and students, church leaders, policy-makers and all those interested in the relationship between religion and public life.
Epigenetic Therapy of Cancer
The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.
