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The Polymerase Chain Reaction
James D. Watson When, in late March of 1953, Francis Crick and I came to write the first Nature paper describing the double helical structure of the DNA molecule, Francis had wanted to include a lengthy discussion of the genetic implications of a molecule whose struc ture we had divined from a minimum of experimental data and on theoretical argu ments based on physical principles. But I felt that this might be tempting fate, given that we had not yet seen the detailed evidence from King's College. Nevertheless, we reached a compromise and decided to include a sentence that pointed to the biological significance of the molecule's key feature-the complementary pairing of the bases. "It has not...
Executing the Supply Chain
MAP, MEASURE, AND GOVERN YOUR SUPPLY CHAIN FOR MAXIMUM BUSINESS VALUE Master proven techniques for mapping, measuring, and improving your supply chain Implement strategies and roadmaps for managing risk and increasing resilience Balance segmentation with standardization, and cost with differentiation Use supply chain KPIs to improve governance Executing the Supply Chain offers expert guidance on driving maximum business value from modern supply chain process mapping and performance measurement. Pioneering supply chain practitioners Alexandre Oliveira and Anne Gimeno introduce powerful techniques for linking processes to customer and shareholder results, systematically managing risk, and incr...
Laboratory Methods for the Detection of Mutations and Polymorphisms in DNA
The analysis of DNA sequence polymorphisms and mutations is of central importance in understanding biological systems. This book is devoted to the experimental analysis of DNA and presents easy-to-follow protocols. Various techniques from the simple to the highly complex are detailed in this volume, providing a wide spectrum of available methods and practical advice. The methods are described in terms of: History and background Principles and theory Equipment and reagents Protocols Troubleshooting Applications Improvements Results Comparisons with other methods Future prospects and developments This is an essential manual for researchers working in human, animal, or plant molecular genetics and is particularly valuable for hospital and commercial laboratories.
Supply Chain
Traditionally supply chain management has meant factories, assembly lines, warehouses, transportation vehicles, and time sheets. Modern supply chain management is a highly complex, multidimensional problem set with virtually endless number of variables for optimization. An Internet enabled supply chain may have just-in-time delivery, precise inventory visibility, and up-to-the-minute distribution-tracking capabilities. Technology advances have enabled supply chains to become strategic weapons that can help avoid disasters, lower costs, and make money. From internal enterprise processes to external business transactions with suppliers, transporters, channels and end-users marks the wide range of challenges researchers have to handle. The aim of this book is at revealing and illustrating this diversity in terms of scientific and theoretical fundamentals, prevailing concepts as well as current practical applications.
Building Lean Supply Chains with the Theory of Constraints
Innovative strategies for building and managing the supply chain using Lean and the Theory of Constraints (TOC) With an emphasis on systems thinking, Building Lean Supply Chains with the Theory of Constraints uniquely integrates TOC with Lean, illustrating how these two philosophies complement and reinforce each other to create the smooth flow of goods and services through the supply chain. The majority of the chapters draw on the tools and techniques of TOC, including throughput accounting, drum-buffer-rope, TOC in distribution and replenishment, the thinking process, and critical chain project management. All of these topics are presented in the context of building and managing a lean supply chain to achieve true bottom line results. Coverage includes: The lean supply chain roadmap Envisioning the lean supply chain: systems thinking Adopting a throughput world perspective Designing products and processes to fulfill customer needs Building a competitive operations strategy Partnering in the lean supply chain Streamlining the value stream Creating flow through the supply chain Managing projects the TOC way: critical chain project management
Complexity Management in Supply Chains
Supply chains are faced with a rising complexity with manifold effects. Because of the strong link between a supply chain's complexity and its efficiency, supply chain complexity management becomes a major challenge of today's business management. Therefore logistics and the supply chain management can play a significant role in mastering and managing complexity. The new book, edited by Thorsten Blecker and Wolfgang Kersten, is exemplifying the current progress in complexity management. Separate chapters are dedicated to clarify complexity management in transportation, networks and supply chains. It offers important insights of global and flexible network modelling to manage complexity, comp...
Saulin
»Saulins Albtraum: Eine Liebe, die zur düsteren Apokalypse führt!« Eine fesselnde Begegnung mit Sarai lässt Saul glauben, er sei in einem unvergesslichen Traum gefangen. Doch ahnt er nicht, dass dieser vermeintliche Traum der Auftakt zu einem unaufhaltsamen Abstieg in den Abgrund seiner eigenen Existenz ist. Überirdische Schrecken dringen immer tiefer in die Stadt vor und eine bösartige Macht aus der Leere des Alls ergreift Besitz von Saul, zerfrisst sein Leben, seinen Verstand und seinen Körper. Um dem Wahnsinn zu entkommen, schließt er einen verheerenden Pakt mit dem Teufel. Doch dieser Weg führt ihn in die Dunkelheit, raubt ihm seine Menschlichkeit und verwandelt ihn in ein albt...
Der Nobiskrug
MYTHEN WERDEN WIRKLICHKEIT - EINE ABENTEUERLICHE SUCHE IM HOHENSTEINGEBIRGE Viele Mythen ranken sich um das Hohensteingebirge. Genau in diese Region verschlägt es Elizabeth, die die Vermutung hat, dass sie ihr Freund Rehor, der vorgibt, in den Bergen wandern zu gehen, betrügt. Gemeinsam mit ihrer Freundin Amelie macht sie sich auf die Suche nach ihm. Beide kehren im Nobiskrug ein, einem abgelegenen Berggasthof, in dem sich merkwürdige Gestalten tummeln. Hier wird ihnen von einem Untier berichtet, das durch die Wälder streift. Angeblich sind bereits viele Touristen dieser grauenhaft schreienden Kreatur zum Opfer gefallen. Kann es sein, dass die alten Sagen der Wirklichkeit entsprechen? EINE NACHT VOLLER GEHEIMNISSE UND SCHRECKEN Als sie die Schreie selbst hören, scheinen sich die schlimmsten Befürchtungen zu bewahrheiten. Trotz aller Warnungen begeben sich die Mädels auf ihre Mission, Rehor zu finden. Dank Amelies Unerschrockenheit und Elizabeths grenzdebilem Humor lassen sich die beiden dabei weder von Teufel persönlich noch von den Tücken moderner Wandersocken aufhalten.
