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In this monograph about gene therapy of autoimmune and inflammatory d- orders we have gathered international experts and leaders from different fields to review the state of the art advances on topics ranging from disease entities to vectors and engineered cells. The different approaches described in each chapter take into consideration the biomedical knowledge of these diseases and address the complexities of delivering long-term genetic interventions. Gene therapy also serves as a testing ground for new therapeutic entities and helps provide proof of principle for their potential therapeutic role in animal models of disease. Scaling up from mice to men still remains an important h- dle not...
This volume features key presentations from the 6th International Congress of Autoimmunity. The International Congress of Autoimmunity has become established as one of the major meetings in the field of immunology, with presentations covering every aspect of basic research in the hopes of clarifying pathogenesis of autoimmune disease as well as providing information on the latest innovations in biological and other modes of treatment. The goal of this volume is to present cutting edge research that focuses in particular on newer diagnostic tools and newer therapies for human autoimmune disease. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.
This is a collection of papers presented at the B Lymphocytes and Autoimmunity conference held on May 21-25, 1996 in Prague. The information presented includes data on B cell subset identification and development, antibody repertoire selection, tolerance induction, and antigen presentation. Each of these has a significant impact on the generation of autoantibodies and the development of autoimmune disease. A multidisciplinary discussion of the basic and clinical aspects of B cell function and autoimmunity is provided.
This book is a printed edition of the Special Issue "Pneumoviruses and Metapneumoviruses" that was published in Viruses
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Mastitis, an inflammation of the mammary glands, is the most costly disease in dairy farming, mainly caused by a broad range of bacteria categorized into contagious and environmental bacteria. This book is a concise summary of mastitis in dairy cattle, sheep, and goats, which mainly focuses on etiological agents, epidemiology, pathogenesis, clinical manifestation, pathological and histopathological changes, diagnosis, prevention, and control measures. This book serves as a textbook on mastitis in dairy cattle, sheep, and goats for dairy veterinarians, veterinary students, animal science students, dairy technicians, animal health professionals. Several researchers worldwide contributed to this book. This book contains the latest information on mastitis in dairy cattle, sheep, and goats and antimicrobial usage to prevent and control mastitis.
Section A: Methods of Autoantibody Detection This Section provides well structured protocols for autoantibody detection. Step-by-step procedures are accompanied by explanatory notes and comments, clear diagrams, line illustrations and excellent photo illustrations. Extensive literature references lead the way to further background information. The methods presented were validated by more than 40 leading laboratories active in sera analysis, which indicates that these methods have been found to be practically useful and lead to consistent inter-laboratory results: consensus in autoantibody detection. Section B: Autoantigens This Section contains the first compilation of full, detailed informa...