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The Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, devastating and fatal disease characterized by selective loss of upper and lower motor neurons of the cerebral cortex, brainstem, spinal cord and muscle atrophy. In spite of many years of research, the pathogenesis of ALS is still not well understood. ALS is a multifaceted genetic disease, in which genetic susceptibility to motor neuron death interacts with environmental factors and there is still no cure for this deleterious disease. At present, there is only one FDA approved drug, Riluzole which according to past studies only modestly slows the progression of the disease, and improves survival by up to three months. The sufferin...
Un-representing the Great War
This collection of essays investigates the multifarious meanings of the Great War considered from a multifaceted perspective as the event that opens up the cultural history of the 20th century. After an introduction delineating ‘unrepresentability’, the core methodological issue of the book, the volume brings together many different strands of analysis and is divided into two main sections: the first provides a cultural and philosophical framework while the second explores specific linguistic and literary issues. Given the variety of perspectives and methodological approaches adopted by the contributors, the volume offers original and useful insights into WWI. The underlying rationale of the book, remaining faithful to the catastrophe of the war, without transforming it into a mere object of scientific investigation or ideological interpretation, helps to shed light on contemporary scenarios.
Typology and Second Language Acquisition
In recent years research on comparative typology has led to reveal regularities and to formulate new constraints upon variation for a broad range of phenomena. As the amount of typological research increased, a growing interest arose for the implications that findings in the typological field might have on second language acquisition. Written by experts in the field of typology and/or second language acquisition, this volume addresses theoretical and empirical issues on structural domains such as relative clauses and possessive constructions as well as pragmatic considerations on information organization in learners productions.
Sociolinguistica
Internationales Jahrbuch für europäische Soziolinguistik.
Relative Constructions in European Non-Standard Varieties
Cross-linguistic studies on relative constructions in European languages are often centred on standard varieties as described in reference grammars. This volume breaks with the tradition in that it investigates relative constructions in non-standard varieties from a multidisciplinary perspective and addresses a crucial question: what does Europe's typological panorama actually look like?
Prosodic and Rhythmic Aspects of L2 Acquisition
In recent years, prosodic competence has become increasingly important in second language acquisition studies, as it is a crucial element in the identification of non-native pronunciation and message understanding. This volume is the first attempt to provide a survey of interlanguage prosody research in L2 Italian. It begins with an overview of the possible approaches to the study of rhythmic-prosodic skills acquisition in an L2. The second part of the book emphasizes the relationship between the mother tongue and a second language, and investigates the presence of transfer in prosody interlanguage development. The third part illustrates prosody’s role in the interpretation of pragmatic meaning in native-non-native interaction, and its influence on message persuasiveness. And in the fourth part, technology meets prosody in the areas of second language teaching and speech synthesis.
Towards a New Standard
In many European languages the National Standard Variety is converging with spoken, informal, and socially marked varieties. In Italian this process is giving rise to a new standard variety called Neo-standard Italian, which partly consists of regional features. This book contributes to current research on standardization in Europe by offering a comprehensive overview of the re-standardization dynamics in Italian. Each chapter investigates a specific dynamic shaping the emergence of Neo-standard Italian and Regional Standard Varieties, such as the acceptance of previously non-standard features, the reception of Old Italian features excluded from the standard variety, the changing standard la...
