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Neuronal Self-Defense: Compensatory Mechanisms in Neurodegenerative Disorders
  • Language: en
  • Pages: 192

Neuronal Self-Defense: Compensatory Mechanisms in Neurodegenerative Disorders

Neurodegenerative disorders are characterized by the progressive loss of specific populations of neurons with consequent deterioration of brain's function and dramatic impact on human behavior. At present, there are no effective cures for neurodegenerative diseases. Because unambiguous diagnosis is possible only after manifestation of symptoms, when a large proportion of neurons has been already lost, therapies are necessarily confined to alleviation of symptoms. Development of cures halting the disease course is hampered by our rudimentary understanding of the etiopathology. Most neurodegenerative disorders are sporadic and age-related and - even for those of known genetic origin - the mech...

The Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments
  • Language: en
  • Pages: 338

The Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, devastating and fatal disease characterized by selective loss of upper and lower motor neurons of the cerebral cortex, brainstem, spinal cord and muscle atrophy. In spite of many years of research, the pathogenesis of ALS is still not well understood. ALS is a multifaceted genetic disease, in which genetic susceptibility to motor neuron death interacts with environmental factors and there is still no cure for this deleterious disease. At present, there is only one FDA approved drug, Riluzole which according to past studies only modestly slows the progression of the disease, and improves survival by up to three months. The sufferin...

Myelin Repair: At the Crossing-Lines of Myelin Biology and Gene Therapy
  • Language: en
  • Pages: 148
Neuronal Calcium Sensors in Health and Disease
  • Language: en
  • Pages: 313
The Journal of Neuroscience
  • Language: en
  • Pages: 622

The Journal of Neuroscience

  • Type: Book
  • -
  • Published: 2009
  • -
  • Publisher: Unknown

None

Storia, antropologia e scienze del linguaggio
  • Language: it
  • Pages: 536

Storia, antropologia e scienze del linguaggio

  • Type: Book
  • -
  • Published: 1995
  • -
  • Publisher: Unknown

None

Rivista Di Linguistica
  • Language: en
  • Pages: 828

Rivista Di Linguistica

  • Type: Book
  • -
  • Published: 2007
  • -
  • Publisher: Unknown

None

La traduzione multimediale
  • Language: en
  • Pages: 486

La traduzione multimediale

  • Type: Book
  • -
  • Published: 2000
  • -
  • Publisher: Unknown

None

Sociolinguistica
  • Language: en
  • Pages: 320

Sociolinguistica

  • Type: Book
  • -
  • Published: 2007
  • -
  • Publisher: Unknown

Internationales Jahrbuch für europäische Soziolinguistik.