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Estradiol is the major steroid hormone which is involved in several organic functions, such as physiological sexual behaviour, development and maintenance of male and female reproductive organs, control of visceral secretion, modulation of immune system, and tumorigenesis. In this compilation, the authors discuss the synthesis, health effects and drug interactions of estradiol. Topics include the occurrence of estradiol in environmental waters; estradiol in the central nervous system and its role in neurodegeneration; the effects of estradiol on male and female reproductive tissues and the influence of endocrine disruptors; estradiol and prostate cancer; hydroxyestradiols and methoxyestradio...
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This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.
The tetracyclines have an illustrious history as therapeutic agents which dates back over half a century. Initially discovered as an antibiotic in 1947, the four ringed molecule has captured the fancy of chemists and biologists over the ensuing decades. Of further interest, as described in the chapter by George Armelagos, tetracyclines were already part of earlier cultures, 1500-1700 years ago, as revealed in traces of drug found in Sudanese Nubian mummies. The diversity of chapters which this book presents to the reader should illus trate the many disciplines which have examined and seen benefits from these fascinating natural molecules. From antibacterial to anti-inflammatory to anti autoimmunity to gene regulation, tetracyclines have been modified and redesigned for various novel properties. Some have called this molecule a biol ogist's dream because of its versatility, but others have seen it as a chemist's nightmare because of the synthetic chemistry challenges and "chameleon-like" properties (see the chapter by S. Schneider).
This unique book is a collaborative effort between researchers at Rutgers University and colleagues from numerous institutions in Uzbekistan and Kyrgyzstan. It will be the first book to document more than 200 of the most important medicinal plants of Central Asia, many whose medicinal uses and activities are being described in English for the first time. The majority of the plants described grow wild in Central Asia with some being endemic, while other species have been introduced to Central Asia but are commonly used in regional plant based medicine. The book contains four introductory chapters. The first and second chapters cover the geography, climate and vegetation of Kyrgyzstan and Uzbe...
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