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Tailor-made Janus Lectin with Dual Avidity Assembles Glycoconjugate Multilayers and Crosslinks Protocells
Abstract: We engineered the first chimeric, bispecific lectin, with two rationally oriented and distinct recognition surfaces. This lectin, coined Janus lectin in allusion to the two-faced roman god, is able to bind independently to both fucosylated and sialylated glycoconjugates. The multivalent presentation of binding sites on each face of the Janus lectin is very efficient, resulting in avidities in the low nanomolar range for both fucosylated and sialylated surfaces. Moreover, novel heterovalent, bifunctional glycoclusters were synthetized that match the topology of the Janus lectin. Based on these tools, we constructed organized and controlled supramolecular architectures by assembling Janus lectin and glycocompound layer-by-layer. Furthermore, the Janus lectin was employed as biomolecular linker to organize protocells made from giant unilamellar vesicles of different nature, to more complex prototissues. In summary, tailor-made Janus lectins open wide possibilities for creating biomimetic matrices or artificial tissues
You're Fired
“You’re fired!” Donald Trump became famous bellowing those words in a make-believe boardroom. In November, tens of millions of Americans want to yell it right back at him. Yet Trump has seemed to almost defy the laws of political physics. Paul Begala, one of America’s greatest political talents, lays out the strategy that will defeat him and send him and his industrial-strength spray-on tan machine back to Mar-a-Lago. In You’re Fired, Paul Begala tells us how Trump uses division to distract from the actual reality of his record. Distraction, he argues, is Trump’s superpower. And this book is Kryptonite. In it, the man who helped elect Bill Clinton and reelect Barack Obama, detail...
The Book of Sarah
Originally published by Myriad Editions.
The Sarah Pekkanen Reader's Companion
In this collection of excerpts, enjoy a taste of Sarah Pekkanen’s captivating novels, including The Opposite of Me, Skipping a Beat, These Girls, and The Best of Us.
A Choice for Sarah
Designed to be used by children in their first six months of school PM Starters One and Two
