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Towards a New 3Rs Era in Experimental Research
With the persisting need of animal experimentation for fundamental and applied research, the relevance and importance of the 3Rs Principle cannot be ignored. The 3Rs Principle was put forward over 50 years ago, providing an essential framework for more humane animal experimentation in research. In this half-century the research landscape within which this principle is applied has dramatically changed and evolved, with ever more emerging venues to explore for 3Rs advancement and implementation.
Antimalarial Medicinal Plants
Malaria continues to affect a large population of the world, especially in third world countries. The spread of drug-resistant parasites demonstrates the need for antimalarial agents with various modes of action. The search for remedies derived from medicinal plants for the treatment of malaria is reliant on accurate ethnobotanical and ethnopharmacological information obtained from traditional medical practitioners. Antimalarial Medicinal Plants provides information on bioactive compounds and therapeutic potentials of several antimalarial plant species found around the globe. This book evaluates these plant species with respect to their biology, diversity, distribution, and pharmacological v...
Animal Testing
« L’expérimentation animale n’existe pas : le tour de force des industries qui y ont recours consiste à l’avoir fait disparaître. » Chaque année, en Europe, environ 12 millions d’animaux subissent des tests : un chiffre qui ne faiblit pas depuis vingt ans malgré une opposition citoyenne croissante et un discours scientifique qui vante la réduction des expériences. Rongeurs, poissons, chats, chiens ou singes sont utilisés dans les laboratoires, et pour des raisons parfois bien éloignées du cadre de la santé. Que vivent vraiment ces animaux ? Pourquoi le changement est-il si lent ? Comment agir ? En créant l’association Animal Testing, Audrey Jougla a pu recueillir des informations et des témoignages inédits. Des années d’enquêtes de terrain ponctuées de déceptions ou de victoires : l’auteur livre un panorama sans concession, aussi clair qu’édifiant. Un récit intime et engagé qui interroge notre humanité face à la condition animale.
Mémoire et intelligence
(extrait, p. 80) Si on se fie aux écrits des neuroscientifiques, ces spécialistes de fonctionnement du cerveau humain, les personnes qui conservent une bonne mémoire et une bonne intelligence malgré le vieillissement, ont très certainement plusieurs points en commun. - Être épargnées des principaux facteurs de risque de démence que sont notamment l'hypertension, l'obésité, la sédentarité, une faible scolarité, l'inactivité intellectuelle, la dépression, le stress intense et l'alcool en excès. - S'être bâti, depuis toujours, une riche réserve physique et cognitive, par des activités variées pour stimuler le maximum d'aires cérébrales et continuer de renflouer cette ré...
Introduction to Frustrated Magnetism
The field of highly frustrated magnetism has developed considerably and expanded over the last 15 years. Issuing from canonical geometric frustration of interactions, it now extends over other aspects with many degrees of freedom such as magneto-elastic couplings, orbital degrees of freedom, dilution effects, and electron doping. Its is thus shown here that the concept of frustration impacts on many other fields in physics than magnetism. This book represents a state-of-the-art review aimed at a broad audience with tutorial chapters and more topical ones, encompassing solid-state chemistry, experimental and theoretical physics.
Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine
Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.
