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Inverse Problems in Engineering Mechanics II
Inverse Problems are found in many areas of engineering mechanics and there are many successful applications e.g. in non-destructive testing and characterization of material properties by ultrasonic or X-ray techniques, thermography, etc. Generally speaking, inverse problems are concerned with the determination of the input and the characteristics of a system, given certain aspects of its output. Mathematically, such problems are ill-posed and have to be overcome through development of new computational schemes, regularization techniques, objective functionals, and experimental procedures. Following the IUTAM Symposium on these topics, held in May 1992 in Tokyo, another in November 1994 in P...
Finite Element Analysis of Electrical Machines
In Finite Element Analysis of Electrical Machines the author covers two-dimensional analysis, emphasizing the use of finite elements to perform the most common calculations required of machine designers and analysts. The book explains what is inside a finite element program, and how the finite element method can be used to determine the behavior of electrical machines. The material is tutorial and includes several completely worked out examples. The main illustrative examples are synchronous and induction machines. The methods described have been used successfully in the design and analysis of most types of rotating and linear machines. Audience: A valuable reference source for academic researchers, practitioners and designers of electrical machinery.
IMACS '91
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Cancer Genome and Tumor Microenvironment
Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ’80s-early ’90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are “soft-wired”, i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.
