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Organic Cation Transporter 1 (OCT1): Not Vital for Life, but of Substantial Biomedical Relevance
Around one third of all biologically relevant small molecules are organic cations. These include endogenous substances like catecholamines and other neurotransmitters, toxins and drugs designed to affect signaling processes. The organic cation transporter 1 (OCT1) is among the strongest expressed membrane transporters at the sinusoidal (blood-facing) side of liver cells and contributes substantially to the clearance of the blood from numerous organic cations. A most striking feature of OCT1 is its pronounced genetic diversity. Between 1 and 10% of all human populations have little to no OCT1 activity. With several of the OCT1 substrates up to 10% of Europeans are functionally OCT1 deficient....
Targets of Cancer Diagnosis and Treatment
This third and final volume in the "Ion Transport in Tumor Biology" collection presents novel diagnostic and therapeutic approaches in cancer based on the exploitation of ion transport proteins. The authors critically examine several transportome members, particularly Na+, K+, Ca2+, and Cl- channels, as well as organic solute carriers regarding their suitability as therapeutic targets. Synergistic effects resulting from the combined use of classical cytostatics with ion transport-inhibiting drugs are pointed out, and the capability of bispecific antibodies to function as anticancer drugs is discussed. As readers will also learn, the use of ion channel inhibitors could improve the outcome of radiotherapy because the development of radio-resistance during radiotherapeutic treatment often correlates with increases in the expression levels and conductance of ion channels. The translational topics of this volume form a bridge between biochemical research and therapeutic application. As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians in the cancer field.
The Odyssey of a Woman Field Scientist
Here, Jean Langenheim presents her odyssey as a woman field scientist, who crossed boundaries of botany, geology, and chemistry in doing ecological studies. The book includes almost two hundred photographs and maps and uses a unique timeline as context for her story in relation to relevant historical events, significant changes in the status of women, and milestones in ecology from the 1920s to the present. Her research spans five continents and ranges from arctic-alpine to tropical environments. It includes many adventures (such as a forced plane landing in Amazonia and working in the midst of a coup dtat in Colombia) and interactions with diverse cultures, from Alaska Eskimo to Ghanain fam...
Bulletin of the History of Medicine
Includes the Transactions of the 15th- annual meetings of the American Association of the History of Medicine, 1939-
