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Antibody-Drug Conjugates and Cellular Metabolic Dynamics
This book summarizes the related research achievements in Antibody-drug conjugates (ADCs) and their cell metabolism kinetics. The book has three main parts. The first part describes the basic theory of ADCs, including the basic concept and structure of ADCs, and the relationship between the targets of ADCs and their specific functions. The second part mainly introduces the endocytosis and intracellular metabolism of ADCs, including the relationship between endocytosis and ADC activity, the endocytosis and intracellular transport of ADCs, the distribution and metabolism of ADC in vivo. Then it discusses the new formats and research technology of ADCs, including the application of miniaturized antibodies in ADC synthesis, novel carriers for ADC design, the technology and application of site-specific conjugation, and approaches for analyzing the drug: antibody ratio (DAR), the study of pharmacokinetics of ADCs. This book combines the basic theory with the research technology. It can be used as a reference book for students, teachers and researchers of biomedical field.
Endocrine Disrupting Chemicals-induced Metabolic Disorders and Treatment Strategies
This volume offers a detailed and comprehensive analysis of Endocrine Disrupting Chemicals (EDCs), covering their occurrence, exposure to humans and the mechanisms that lead to the parthogenesis of EDCs-induced metabolic disorders. The book is divided into three parts. Part I describes the physiology of the human endocrine system, with special emphasis on various types of metabolic disorders along with risk factors that are responsible for the development of these disorders. Part II addresses all aspects of EDCs, including their role in the induction of various risk factors that are responsible for the development of metabolic disorders. Part III covers up-to-date environmental regulatory considerations and treatment strategies that have been adopted to cure and prevent EDCs-induced metabolic disorders. This section will primarily appeal to clinicians investigating the causes and treatment of metabolic disorders. The text will also be of interest to students and researchers in the fields of Environmental Pharmacology and Toxicology, Environmental Pollution, Pharmaceutical Biochemistry, Biotechnology, and Drug Metabolism/Pharmacokinetics.
Insights from Visitor Studies
Insights from Visitor Studies: A purpose-oriented model for museums provides a systematic overview of the value of visitor studies and, for the first time in English, a comprehensive overview of the development of visitor studies in mainland China. This book emphasizes the importance of approaching visitor studies with a focus on purpose-oriented way and introduces the PSD model based on it. Zhao suggests that when museums aim to use the results of visitor research to gain support, or when they want to conduct a visitor evaluation to address a specific issue, they can follow the logical sequence of Purpose, Standpoint, and Dimension for analysis and identification. This approach will help mu...
Polygamy and Sublime Passion
For centuries of Chinese history, polygamy and prostitution were closely linked practices that legitimized the "polygynous male," the man with multiple sexual partners. Despite their strict hierarchies, these practices also addressed fundamental antagonisms in sexual relations in serious and constructive ways. Qing fiction abounds in stories of female resistance and superiority. Women—main wives, concubines, and prostitutes—were adept at exerting control and gaining status for themselves, while men indulged in elaborate fantasies about female power. In Polygamy and Sublime Passion, Keith McMahon introduces a new concept, "passive polygamy," to explain the unusual number of Qing stories i...
Mommy, Daddy Says I Am Adopted
Six years ago, she broke into a stranger's room...Six years later, she returned to the city and brought back a handsome boy by her side.In order to support herself and her son, she worked as a maid, and was happy to do so.The young master was not good－tempered, but he was quite tolerant of her as a maid, to the extent that she felt she was about to fall in love with him, and her heart beat non－stop when she saw him. ...In the Cafe.Doria looked at her date and smiled, "I don't ask for much, as long as you don't treat my son badly."The man smiled, "I like kids. I can take him to the playground."At the next table, Gale slammed his cup, snorted, and ordered his assistant to buy the playgroun...
HLA Typing
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Advances in Mechanism, Machine Science and Engineering in China
This book presents the conference proceedings of the 23rd IFToMM China International Conference on Mechanism and Machine Science & Engineering (IFToMM CCMMS 2022). CCMMS was initiated in 1982, and it is the most important forum held in China for the exchange of research ideas, presentation of technical and scientific achievements, and discussion of future directions in the field of mechanism and machine science. The topics include parallel/hybrid mechanism synthesis and analysis, theoretical & computational kinematics, compliant mechanisms and micro/nano-mechanisms, reconfigurable and metamorphic mechanisms, space structures, mechanisms and materials, structure adaptation in space environmen...
Colonial Taiwan
This book offers a thorough and thought-provoking study on the impact of Japanese colonialism on Taiwan’s literary production from the 1920s to 1945. It redresses the previous nationalist and Japan-centric interpretations of works from Taiwan’s Japanese period, and eschews a colonizer/colonized dichotomy. Through a highly sensitive textual analysis and contextual reading, this chronologically structured book paints a multi-layered picture of colonial Taiwan’s literature, particularly its multi-styled articulations of identities and diverse visions of modernity. By engaging critically with current scholarship, Lin has written with great sentiment the most complete history of the colonial Taiwanese literary development in English.
