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Biomarkers in Drug Hypersensitivity
Biomarkers, especially those based on pharmacogenomics testing, have proved to be extremely useful for type A adverse drug reactions. Clinical practice guidelines based on biomarker testing are presently being developed and updated for type A adverse drug reactions. In contrast, little attention has been paid to the potential use of biomarkers in type B adverse reactions, characterized by the occurrence of reactions not directly related to the pharmacological properties of the drug. Drug-induced hypersensitivity belongs to those type B reactions. Drug-induced hypersensitivity reactions involve complex mechanisms that include, among others, the metabolic activation and haptenization of drug m...
Challenges at the Interface of Data Analysis, Computer Science, and Optimization
This volume provides approaches and solutions to challenges occurring at the interface of research fields such as data analysis, computer science, operations research, and statistics. It includes theoretically oriented contributions as well as papers from various application areas, where knowledge from different research directions is needed to find the best possible interpretation of data for the underlying problem situations. Beside traditional classification research, the book focuses on current interests in fields such as the analysis of social relationships as well as statistical musicology.
Progress in Medical Geology
This volume represents a compendium of research conducted by international scholars who participated in the 2nd Symposium on Advances in Geospatial held during “The 5th International Conference on Medical Geology” in Arlington, Virginia, USA, in 2013. The research topics dealt with here mainly focus on the new scientific field of medical geology used to address a variety of human health issues and diseases specifically related to geological materials and earth-system processes. This volume will be of interest to those who wish to learn about current and historical health issues relating to geological materials or other environmental factors. It also represents a useful guide to learning the interdisciplinary approach to problem-solving in the field of medical geology.
Diagnostic, Prognostic and Predictive Biomarkers in Prostate Cancer
This book is a printed edition of the Special Issue "Diagnostic, Prognostic and Predictive Biomarkers in Prostate Cancer" that was published in IJMS
Biomarkers in Drug Hypersensitivity
Biomarkers, especially those based on pharmacogenomics testing, have proved to be extremely useful for type A adverse drug reactions. Clinical practice guidelines based on biomarker testing are presently being developed and updated for type A adverse drug reactions. In contrast, little attention has been paid to the potential use of biomarkers in type B adverse reactions, characterized by the occurrence of reactions not directly related to the pharmacological properties of the drug. Drug-induced hypersensitivity belongs to those type B reactions. Drug-induced hypersensitivity reactions involve complex mechanisms that include, among others, the metabolic activation and haptenization of drug m...
Quantitative Methods in Corpus-based Translation Studies
This is a comprehensive guidebook to the quantitative methods needed for Corpus-Based Translation Studies (CBTS). It provides a systematic description of the various statistical tests used in Corpus Linguistics which can be used in translation research. In Part 1, Theoretical Explorations, the interplay between quantitative and qualitative methodologies is explored. Part 2, Essential Corpus Studies, describes how to undertake quantitative studies, with a suitable level of technical and relevant case studies. Part 3, Quantitative Explorations of Literary Translations, looks at translations of classic works by Cao Xueqin, James Joyce and other authors. Finally, Part 4 on Translation Lexis uses a variety of techniques new to translation studies, including multivariate analysis and game theory. This book is aimed at students and researchers of corpus linguistics, translation studies and quantitative linguistics. It will significantly advance current translation studies in terms of methodological innovation and will fill in an important gap in the development of quantitative methods for interdisciplinary translation studies.
Faszination Statistik
Dieser Sammelband zeigt an ausgewählten Beispielen, wie spannend und vielfältig statistische Forschung sein kann. Ob es nun darum geht, hörgeschädigten Menschen einen guten Musikgenuss zu verschaffen, aus Texten sinnvolle quantitative Daten zu extrahieren oder Überschwemmungskatastrophen zu modellieren und damit besser in den Griff zu bekommen – die meisten in diesem Buch dargestellten Erkenntnisse sind nicht in Lehrbüchern zu finden, sie stammen direkt von der Forschungsfront und laden zum Staunen und Entdecken ein. Auf Fachjargon und Formalismus wird bei der Darstellung so weit wie möglich verzichtet – das Buch richtet sich somit an jeden, der sich für das aktuelle Forschungsge...
Swimming to Elba
A sensually charged novel about two girls growing up fast in a failing industrial town on the coast of Italy Anna and Francesca are on the brink of everything: high school, adulthood, and the edge of ambition in their provincial town. It’s summer in Piombino, Italy, and in their skimpy bathing suits, flaunting their newly acquired curves, the girls suddenly have everyone in their thrall. This power opens their imagination to a destiny beyond Piombino; the resort town of Elba is just a ferry ride away and yet they’ve never dared to go. Maybe the future is waiting for them there, or somewhere beyond. When their friendship suffers a blow, the girls set off on their own only to discover that their budding sexuality takes them further than they expect, though not as far as their dreams. As their choices take them to a painful crossroads, the girls must reconnect if they have any hope of escaping their small town destinies. In this poetic, prizewinning debut, Silvia Avallone captures the lost innocence of a generation. Harrowing yet ultimately redemptive, Swimming to Elba is a story about the power of friendship, and the way that family, friendship, and economics shape our world.
Silvie
Silvia lived through one of the darkest periods in history, yet emerged with an unstoppable passion for life.--Steven Spielberg
