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Written by outstanding scientists in physics and molecular biology, this book addresses the most recent advances in the analysis of the protein folding processes and protein structure determination. Emphasis is also placed on modelling and presentation of experimental results of structural membrane bound proteins. Many color plates help to illustrate structural aspects covered including: Defining folds of protein domains Structure determination from sequence Distance geometry Lattice theories Membrane proteins Protein-Ligand interaction Topological considerations Docking onto receptors All analysis is presented with proven theory and experimentation. Protein Folds: A Distance-Based Approach is an excellent text/reference for biotechnologists and biochemists as well as graduate students studying in the research sciences.
An account of key ideas and algorithms in reinforcement learning. The discussion ranges from the history of the field's intellectual foundations to recent developments and applications. Areas studied include reinforcement learning problems in terms of Markov decision problems and solution methods.
An overview of the theory and application of kernel classification methods. Linear classifiers in kernel spaces have emerged as a major topic within the field of machine learning. The kernel technique takes the linear classifier—a limited, but well-established and comprehensively studied model—and extends its applicability to a wide range of nonlinear pattern-recognition tasks such as natural language processing, machine vision, and biological sequence analysis. This book provides the first comprehensive overview of both the theory and algorithms of kernel classifiers, including the most recent developments. It begins by describing the major algorithmic advances: kernel perceptron learni...
A comprehensive introduction to Support Vector Machines and related kernel methods.
Fundamental theory and practical algorithms of weakly supervised classification, emphasizing an approach based on empirical risk minimization. Standard machine learning techniques require large amounts of labeled data to work well. When we apply machine learning to problems in the physical world, however, it is extremely difficult to collect such quantities of labeled data. In this book Masashi Sugiyama, Han Bao, Takashi Ishida, Nan Lu, Tomoya Sakai and Gang Niu present theory and algorithms for weakly supervised learning, a paradigm of machine learning from weakly labeled data. Emphasizing an approach based on empirical risk minimization and drawing on state-of-the-art research in weakly su...
The first comprehensive guide to distributional reinforcement learning, providing a new mathematical formalism for thinking about decisions from a probabilistic perspective. Distributional reinforcement learning is a new mathematical formalism for thinking about decisions. Going beyond the common approach to reinforcement learning and expected values, it focuses on the total reward or return obtained as a consequence of an agent's choices—specifically, how this return behaves from a probabilistic perspective. In this first comprehensive guide to distributional reinforcement learning, Marc G. Bellemare, Will Dabney, and Mark Rowland, who spearheaded development of the field, present its key...
A new edition of a graduate-level machine learning textbook that focuses on the analysis and theory of algorithms. This book is a general introduction to machine learning that can serve as a textbook for graduate students and a reference for researchers. It covers fundamental modern topics in machine learning while providing the theoretical basis and conceptual tools needed for the discussion and justification of algorithms. It also describes several key aspects of the application of these algorithms. The authors aim to present novel theoretical tools and concepts while giving concise proofs even for relatively advanced topics. Foundations of Machine Learning is unique in its focus on the an...
A comprehensive introduction to machine learning that uses probabilistic models and inference as a unifying approach. Today's Web-enabled deluge of electronic data calls for automated methods of data analysis. Machine learning provides these, developing methods that can automatically detect patterns in data and then use the uncovered patterns to predict future data. This textbook offers a comprehensive and self-contained introduction to the field of machine learning, based on a unified, probabilistic approach. The coverage combines breadth and depth, offering necessary background material on such topics as probability, optimization, and linear algebra as well as discussion of recent developm...
"There are fundamental principles for problem analysis and algorithm design that are continuously used in bioinformatics. This book concentrates on a clear presentation of these principles, presenting them in a self-contained, mathematically clear and precise manner, and illustrating them with lots of case studies from main fields of bioinformatics. Emphasis is laid on algorithmic "pearls" of bioinformatics, showing that things may get rather simple when taking a proper view into them. The book closes with a thorough bibliography, ranging from classic research results to very recent findings, providing many pointers for future research. Overall, this volume is ideally suited for a senior undergraduate or graduate course on bioinformatics, with a strong focus on its mathematical and computer science background."--BOOK JACKET.
An accessible, authoritative, and up-to-date computer vision textbook offering a comprehensive introduction to the foundations of the field that incorporates the latest deep learning advances. Machine learning has revolutionized computer vision, but the methods of today have deep roots in the history of the field. Providing a much-needed modern treatment, this accessible and up-to-date textbook comprehensively introduces the foundations of computer vision while incorporating the latest deep learning advances. Taking a holistic approach that goes beyond machine learning, it addresses fundamental issues in the task of vision and the relationship of machine vision to human perception. Foundatio...