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Fast Facts: Treatment Optimization of Motor Fluctuations in Parkinson's Disease
Although dopaminergic medication is the most effective treatment for patients with Parkinson’s disease (PD), its long-term use is associated with debilitating motor fluctuations. Patients may not spontaneously seek assistance when fluctuations develop, so strategies need to be put in place to identify and alleviate motor dysfunction. This concise resource will increase readers’ awareness of: • the different types of motor fluctuation, why they occur and how to recognize them • the drugs that can be added to levodopa to reduce fluctuations • advanced and emerging therapies that will help to improve outcomes. No two patients with PD are alike in their disease progression or response to treatment. This 'Fast Facts' title provides the information healthcare professionals need to provide effective individualized care that will improve their patients’ quality of life.
Parkinson's Disease
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Drug Repurposing
Drug repurposing, or repositioning, is the development of existing drugs for new uses: given that 9 in 10 drugs that enter drug development are never marketed and therefore represent wasted effort, it is an attractive as well as inherently more efficient process. Three repurposed drugs can be brought to market for the same cost as one new chemical entity; and they can also be identified more quickly, an important benefit for patients whose diseases are progressing faster than therapeutic innovation. But repurposing also requires a fresh look at configuring pharmaceutical R&D, considering clinical, regulatory and patent issues much earlier than would otherwise be the case. In addition to new ways of thinking, the discovery of repurposing opportunities can take advantage of artificial intelligence techniques to match the perfect new use for an existing drug. This book provides an ideal introduction to the field of drug repurposing with contributions from world-renowned experts culminating in an excellent resource for any drug discovery or medicinal chemist.
Fast Facts: Ottimizzazione del trattamento delle fluttuazioni motorie nella malattia di Parkinson
Sebbene la terapia dopaminergica rappresenti la forma di trattamento più efficace per i pazienti con malattia di Parkinson (MP), l’uso a lungo termine di questi farmaci è associato a fluttuazioni motorie invalidanti. Poiché i pazienti potrebbero non richiedere spontaneamente assistenza quando si manifestano fluttuazioni, occorre adottare opportune strategie per identificare e alleviare la disfunzione motoria. Questo breve opuscolo intende sensibilizzare il lettore su quanto segue: • le diverse tipologie di fluttuazione motoria, il motivo per cui si manifestano e come riconoscerle • i farmaci eventualmente associabili alla levodopa per ridurre le fluttuazioni • terapie avanzate ed ...
Fast Facts: Optimización del tratamiento de las fluctuaciones motoras en la enfermedad de Parkinson
Aunque la medicación dopaminérgica es el tratamiento más eficaz para los pacientes que padecen la enfermedad de Parkinson (EP), su uso prolongado está asociado con fluctuaciones motoras debilitantes. Es posible que los pacientes no busquen inmediatamente asistencia médica cuando aparecen las fluctuaciones, por eso es necesario implementar estrategias que permitan identificar y aliviar la disfunción motora. Este conciso recurso permitirá a los lectores conocer mejor: • los diferentes tipos de fluctuaciones motoras, por qué se producen y cómo reconocerlas • los fármacos que se pueden añadir a la levodopa para reducir las fluctuaciones • las terapias avanzadas y emergentes que ayudan a mejorar los resultados. No hay dos pacientes parkinsonianos con el mismo progreso de la enfermedad ni la misma respuesta al tratamiento. Esta obra Fast Facts proporciona a los profesionales de la salud la información que necesitan para ofrecer a sus pacientes una atención personalizada que mejore su calidad de vida.
Movement Disorders—Advances in Research and Treatment: 2012 Edition
Movement Disorders—Advances in Research and Treatment: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Movement Disorders. The editors have built Movement Disorders—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Movement Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Movement Disorders—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Advances in Clinical Chemistry
Advances in Clinical Chemistry, Volume 103, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry. It is the benchmark publication for novel analytical approaches in the clinical laboratory. Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science Authored by world renowned clinical laboratory scientists, physicians and research scientists Presents the international benchmark for novel analytical approaches in the clinical laboratory
Brain-Computer Interface Research
The Annual BCI Research Awards are international prizes that recognize the top new projects in brain–computer interface (BCI) research. This book contains concise descriptions of projects nominated for the 2019 BCI Research Award and interviews with nominees. Each article is authored by the researchers who developed the project, and articles have been updated with new progress achieved since their nomination. These chapters are complemented by an introduction by the editors together with a concluding chapter that reviews the annual Awards Ceremony, announces the winners, and ends with a brief discussion. One of the prominent trends in recent years has been the development of BCIs for new patient groups. Many chapters in this book present emerging and novel research directions likely to become more prevalent in the near future. This year's book includes chapters based on interviews with BCI experts who were nominated for an award, including this year's first, second, and third place winners. These interview chapters are generally less technical than project descriptions, and provide individual perspectives from people actively working on new methods and systems.
Cardiovascular and Metabolic Disease
Cardiovascular and metabolic diseases remain the number one cause of death in developed countries and their prevalence is increasing rapidly in developing nations. This book brings together the recent information on these disorders and the links that exist between them in order to provide a complete picture of drug discovery for these conditions. The main three sections comprehensively discuss obesity, hypertension and cardiovascular disease, and diabetes in turn, following an introduction to the molecular links between them. The final chapter provides perspectives on future directions of the field. Chapters are contributed by leaders in the field from academia and industry and cover biomark...
Medifocus Guidebook on
The MediFocus Guidebook on Parkinson's Disease is the most comprehensive, up-to-date source of information available. You will get answers to your questions, including risk factors of Parkinson's Disease, standard and alternative treatment options, leading doctors, hospitals and medical centers that specialize in Parkinson's Disease, results of the latest clinical trials, support groups and additional resources, and promising new treatments on the horizon. This one of a kind Guidebook offers answers to your critical health questions including the latest treatments, clinical trials, and expert research; high quality, professional level information you can trust and understand culled from the latest peer-reviewed journals; and a unique resource to find leading experts, institutions, and support organizations including contact information and hyperlinks. This Guidebook was updated on January 23, 2012.
