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Nanoparticles in Cancer Therapy
This book presents the role of nanoparticles in cancer therapy, emphasizing their innovative applications across treatment, diagnosis and the development of therapeutic strategies. The first section of the book describes the applications of nanoparticles in cancer vaccines and gene therapy. It features discussions on polymeric nanoparticles as nanovaccine carriers, membrane-based nano-vaccines for immunotherapy and gene therapy techniques employing nanoparticles. The second section presents advanced nanomedicine approaches, specifying the role of chemodynamic nanoparticles in cancer theranostics, the application of low-dimensional nanomaterials and emerging strategies against drug resistance...
Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer
This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein–protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock and key theory. The author achieved the first total synthesis of TB1 and its spin-labeled derivative to carry out NMR experiments because the supply of TB1 from natural sources was limited. Unique 2,2’,6,6’-tetrasubstituted diphenyl ether moiety of TB1 was synthesized from a depsidone skeleton by che...
Existence of Unimodular Triangulations–Positive Results
Unimodular triangulations of lattice polytopes arise in algebraic geometry, commutative algebra, integer programming and, of course, combinatorics. In this article, we review several classes of polytopes that do have unimodular triangulations and constructions that preserve their existence. We include, in particular, the first effective proof of the classical result by Knudsen-Mumford-Waterman stating that every lattice polytope has a dilation that admits a unimodular triangulation. Our proof yields an explicit (although doubly exponential) bound for the dilation factor.
Nanobiotechnology
This book covers topics related to drug delivery, biomaterials, drug design, formulation development, nanoscience, and nanotechnology. It describes the fundamental concepts in nanotechnology and their different applications in biotechnology to solve engineering challenges and generate new areas of technological development. Nanobiotechnology: Applications of Nanomaterials in Biotechnology, Medicine, and Healthcare covers vast application areas that include medical science, material science, pharmaceutical science, and environmental science. Section 1 presents recent research updates on the different nanomaterials, which are promising in different medical and biotechnological applications. Ap...
Linear Algebra in Action
This book is based largely on courses that the author taught at the Feinberg Graduate School of the Weizmann Institute. It conveys in a user-friendly way the basic and advanced techniques of linear algebra from the point of view of a working analyst. The techniques are illustrated by a wide sample of applications and examples that are chosen to highlight the tools of the trade. In short, this is material that the author has found to be useful in his own research and wishes that he had been exposed to as a graduate student. Roughly the first quarter of the book reviews the contents of a basic course in linear algebra, plus a little. The remaining chapters treat singular value decompositions, ...
Periods of Quaternionic Shimura Varieties. I.
This book formulates a new conjecture about quadratic periods of automorphic forms on quaternion algebras, which is an integral refinement of Shimura's algebraicity conjectures on these periods. It also provides a strategy to attack this conjecture by reformulating it in terms of integrality properties of the theta correspondence for quaternionic unitary groups. The methods and constructions of the book are expected to have applications to other problems related to periods, such as the Bloch-Beilinson conjecture about special values of $L$-functions and constructing geometric realizations of Langlands functoriality for automorphic forms on quaternion algebras.
Handbook of Organopalladium Chemistry for Organic Synthesis
Organized to provide maximum utility to the bench synthetic chemist. The editor is well-known for his work in exploring, developing, and applying organopalladium chemistry. Contributors include over 24 world authorities in the field.
Combinatorial Reciprocity Theorems
Combinatorial reciprocity is a very interesting phenomenon, which can be described as follows: A polynomial, whose values at positive integers count combinatorial objects of some sort, may give the number of combinatorial objects of a different sort when evaluated at negative integers (and suitably normalized). Such combinatorial reciprocity theorems occur in connections with graphs, partially ordered sets, polyhedra, and more. Using the combinatorial reciprocity theorems as a leitmotif, this book unfolds central ideas and techniques in enumerative and geometric combinatorics. Written in a friendly writing style, this is an accessible graduate textbook with almost 300 exercises, numerous illustrations, and pointers to the research literature. Topics include concise introductions to partially ordered sets, polyhedral geometry, and rational generating functions, followed by highly original chapters on subdivisions, geometric realizations of partially ordered sets, and hyperplane arrangements.
Web Accessibility
Covering key areas of evaluation and methodology, client-side applications, specialist and novel technologies, along with initial appraisals of disabilities, this important book provides comprehensive coverage of web accessibility. Written by leading experts in the field, it provides an overview of existing research and also looks at future developments, providing a much deeper insight than can be obtained through existing research libraries, aggregations, or search engines.
