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Abstract: Cell state-, developmental stage-, and lineage-specific combinatorial expression of cluster of differentiation (CD) molecules enables the identification of cellular subsets via multicolor flow cytometry. We describe an exhaustive characterization of neural cell types by surface antigens, exploiting human pluripotent stem cell-derived neural cell systems. Using multiwell screening approaches followed by detailed validation of expression patterns and dynamics, we exemplify a strategy for resolving cellular heterogeneity in stem cell paradigms. In addition to providing a catalog of surface antigens expressed in the neural lineage, we identified the transferrin receptor-1 (CD71) to be differentially expressed in neural stem cells and differentiated neurons. In this context, we describe a role for N-Myc proto-oncogene (MYCN) in maintaining CD71 expression in proliferating neural cells. We report that in vitro human stem cell-derived neurons lack CD71 surface expression and that the observed differential expression can be used to identify and enrich CD71− neuronal derivatives from heterogeneous cultures
No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
Arthritis: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Arthritis: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Arthritis: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
In 2016 Current Topics in Developmental Biology (CTDB) will celebrate its 50th or “golden anniversary. To commemorate the founding of CTDB by Aron Moscona (1921-2009) and Alberto Monroy (1913-1986) in 1966, a two-volume set of CTDB (volumes 116 and 117), entitled Essays on Development, will be published by Academic Press/Elsevier in early 2016. The volumes are edited by Paul M. Wassarman, series editor of CTDB, and include contributions from dozens of outstanding developmental biologists from around the world. Overall, the essays provide critical reviews and discussion of developmental processes for a variety of model organisms. Many essays relate the history of a particular area of research, others personal experiences in research, and some are quite philosophical. Essays on Development provides a window onto the rich landscape of contemporary research in developmental biology and should be useful to both students and investigators for years to come. Covers the area of developmental processes for a variety of model organisms International board of authors Part of two 50th Anniversary volumes proving a comprehensive set of reviews edited by Serial Editor Paul M. Wassarman
The story of a 9 year old girl named Traveling Teresa. She loves her grandparents and she loves to travel. One day she finds a mysterious little red suitcase in her grandparents' attic and her life is never the same again.
This biography of the "First Family" of anthropology reveals how their discoveries, collaborations, and rivalries contributed to our own knowledge of the origins of humankind. In this fascinating and authoritative work, acclaimed science writer Virginia Morell brings to vivid life the famous and infamous Leakey family, pioneers in the field of paleoanthropology: Louis Leakey, the patriarch, who persisted through initial scientific failures and scandal-ridden divorce to achieve spectacular success in digs throughout East Africa; Mary, his second wife, who worked alongside Louis as they made their outstanding discoveries at Olduvai Gorge and elsewhere; and Richard, their son, who ascended to the top of the field in his parents’ wake, only to be threatened with both near-fatal illness and fierce professional rivalry. Morell transports us into the world of these compelling personalities, demonstrating how a small clan of highly talented and fiercely competitive people came to dominate an entire field of science and to contribute immeasurably to our understanding of the origins of humanity.
For fans of Educated, Captive, and Leah Remini's Troublemaker comes the gripping true-life story of one young woman's accidental journey into a cult. And her escape a decade later. It's rarely obvious when a group is a cult. Most cults don't advertise themselves as such: they are groups of people who look and act just like you and me. Not dangerous. Not deranged. At least, not at first. The slide toward complete control of your personality, your thoughts, and your life is slow and virtually unnoticeable. Until it's too late. Cult, A Love Story has been studied in university classrooms, featured in an audio documentary and on podcasts, and read by cult survivors and their families all over th...