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Tetanus
Discusses tetanus, including causes, symptoms, treatment, and preventative measures.
Tetanus Surveillance
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Neonatal Tetanus Elimination
This publication is one of a series of practical field guides produced by the Pan American Health Organization with best practice guidance for immunisation programmes in the region. This guide describes the strategies that have made the elimination of neonatal tetanus in the Americas possible, highlighting the progress made in surveillance to identify and monitor high-risk areas as well as immunisation activities geared towards women of childbearing age who live in those areas. Sections cover: epidemiology, clinical aspects, case definitions and investigations, surveillance, data analysis, control in high risk areas, programme monitoring, vaccine storage and supply.
Tetanus
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Clostridial Neurotoxins
Tetanus has been known from the very beginning of medical literature since it was first described by Hyppocrates of Cos in the fifth century B.C. For 24 centuries it was considered a neuro logical disease until the breakthrough of CARLE and RATIONE (1884) who demonstrated its infectious etiology. Following the establishment of purified cultures of Clostridium tetani(KITASATO 1889), FABER (1890), and TIZZONI and CATIANI (1890) demon strated that the disease is actually an intoxication caused by a proteic neurotoxin. This toxin was shown by BRUSHCHETIINI (1892) to move retroaxonally and to act at the spinal cord level. Soon thereafter VAN ERMENGEN (1897) demonstrated that botu lism is also due...
Tetanus
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