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Tumor Cell Heterogeneity in Small Cell Lung Cancer (SCLC): Phenotypical and Functional Differences Associated with Epithelial-mesenchymal Transition (EMT) and DNA Methylation Changes
Abstract: Small Cell Lung Cancer (SCLC) is a specific subtype of lung cancer presenting as highly metastatic disease with extremely poor prognosis. Despite responding initially well to chemo- or radiotherapy, SCLC almost invariably relapses and develops resistance to chemotherapy. This is suspected to be related to tumor cell subpopulations with different characteristics resembling stem cells. Epithelial-Mesenchymal Transition (EMT) is known to play a key role in metastatic processes and in developing drug resistance. This is also true for NSCLC, but there is very little information on EMT processes in SCLC so far. SCLC, in contrast to NSCLC cell lines, grow mainly in floating cell clusters ...
Tumor Budding in Colorectal Cancer
Tumour "budding", which is focused on in this book, is generally defined as an isolated single cancer cell or a cluster composed of a very small number of undifferentiated cancer cells in the stroma of the actively invasive front. The correlation of tumour budding with clinical outcome in colorectal cancer was first reported in the 1980s by Japanese surgeons. Since then, the clinical usefulness of this finding in colorectal cancer has been recognised in many countries. Its usefulness has been clarified not only as a prognostic factor and a potential parameter for a grading system, but also as an indicator for therapeutic decision making. Recently, more objective evaluation of tumour budding has been advocated, and the underlying mechanisms of tumour budding formation have been investigated at the molecular level. In this book, tumour budding in colorectal cancer is discussed from various perspectives. This book provides useful information for all investigators trying to deepen their understanding of colorectal cancer and develop evidence-based therapeutic strategies.
The Biology of Cancer
Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world.The Biology of Cancer is a textbook for students studying the molecular and cellula
Metastasis of Colorectal Cancer
Colorectal cancer is the third most common cancer worldwide, and in many parts of the western world, it is the second leading cause of cancer-related deaths. This book covers colon cancer metastasis from the most fundamental aspects to clinical practice. Major topics include physiopathology, genetic and epigenetic controls, cancer initiating cells, epithelial-mesenchymal transition, growth factors and signalling, cell adhesion, natures of liver metastasis, angiogenesis and lymphangiogenesis, inflammatory response, prognostic markers, sentinel node and staging, and finally diagnosis and treatment. Each chapter has been contributed by leaders in the field. A key feature is that it connects with a large readership including students, fundamentalists and clinicians. Another specific feature of the book is that the chapters are written in a didactic and illustrative fashion. These characteristics coupled with the choice of the topics and authors, makes this book a reference in the field. It represents an essential acquisition for medical libraries, clinicians as well as medical and graduate students.
Cell Adhesion
This book provides an overview of the main topics of current cell adhesion research including structural analyses of cell adhesion molecules and studies to their functional role in vitro and in vivo. The present volume focuses on the four major families of cell-adhesion receptors, i.e. the cadherins, the integrins, the Ig-superfamily and the selectin-based adhesion system which are discussed in detail by numerous experts in the field.
Cancer Stem Cells
An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy. Rather than treat cancer by aggressively trying to eliminate all cancerous cells—with harmful side effects for patients—CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells—the abilities to self-renew and to differentiate. According to this theory, o...
ICT for Health Science Research
Information and Communications Technology (ICT) is used in healthcare and health science research in application domains such as clinical trials and the development of drug and medical devices, as well as in translational medicine, with the aim of improving prevention, diagnosis, and interventions in health and care. This book presents accepted papers from the 2019 European Federation of Medical Informatics conference (EFMI STC 2019), held in Hanover, Germany, from 7 – 10 April 2019. More than 90 submissions were received, from which, after review, the Scientific Program Committee (SPC) accepted 50 full papers to be included in this volume of proceedings. In addition, 16 poster presentatio...
Metastatic Progression and Tumour Heterogeneity
Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.
