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A Phase II Trial to Evaluate the Combination of Pixantrone and Obinutuzumab for Patients with Relapsed Aggressive Lymphoma: Final Results of the Prospective, Multicentre GOAL Trial
Abstract: The prognosis of patients with relapsed diffuse large B-cell lymphoma (DLBCL) remains poor with current options. Here we prospectively evaluated the combination of pixantrone with obinutuzumab for up to six cycles for patients with relapsed or refractory DLBCL. Overall response rate (ORR) was the primary end-point. Sixty-eight patients were evaluated, median age was 75 years, median number of prior lines was three (range 1-10), 52 patients (76.5%) were diagnosed with DLBCL and 16 (23.5%) patients had transformed indolent lymphoma or follicular lymphoma (FL) IIIB. ORR was 35.3% for all and 40% for evaluable patients (16.6% complete response), median progression-free survival (PFS) a...
"... dass einmal dem Juden das Land auf diese Weise abgenommen wird ..."
Die Geschichte der jüdischen Einwohner von Enkirch und der jüdischen Gemeinde von der napoleonischen Zeit bis zur Auflösung der Gemeinde durch die Nationalsozialisten und der Verfolgung der Mitglieder, die in Vertreibung und Exil oder Deportation und Ermordung während des Holocaust mündete. Aktualisierte und ergänzte Auflage
The Ways of Federalism in Western Countries and the Horizons of Territorial Autonomy in Spain
Territorial autonomy in Spain has reached a crossroads. After over thirty years of development, the consensus regarding its appropriateness has started to crumble. The transformation project embodied by the reform of Statute of Catalonia (2006) has failed to achieve its most significant demands. Although the concept of Spain as a Federation is disputed -more within the country than beyond-, the evolution of the Spanish system needs to follow a markedly federalist path. In this perspective, reference models assume critical importance. This edition gathers the works of a broad group of European, American and Spanish experts who analyse the present-day challenges of their respective systems. Th...
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