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Diagnosis and Management of Mitochondrial Disorders
This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world’s foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.
Diagnosis and Management of Mitochondrial Disorders
This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world's foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.
Modern Discoveries in Neuroscience... And What They Reveal About You (Collection)
3 remarkable books reveal what neuroscientists have just learned about your brain — and you! Neuroscientists have made absolutely stunning discoveries about the brain: discoveries that are intimately linked to everything from your health and happiness to the age-old debate on free will. In these three extraordinary books, leading scientists and science journalists illuminate these discoveries, helping you understand what they may mean — and what may come next. In Brains: How They Seem to Work, Dale Purves reviews the current state of neuroscientific research, previewing a coming paradigm shift that may transform the way scientists think about brains yet again. Building on new research on...
Mouse as a Model Organism
Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in vivo. Due to its small size, its short reproduction time, and the possibility to introduce specific gen...
Hereditary Optic Neuropathies: A New Perspective
Topic Editor Valerio Carelli received financial support from Stealth BioTherapeutics. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
The Root of Thought
Discover the Other 90% of Your Brain Learn about brain science breakthroughs that might hold the key to intelligence, creativity, and imagination. Discover amazing cells that keep your brain growing, adapting, and healing. Preview possible breakthroughs for brain cancer, brain trauma, Alzheimer's, Parkinson's, and even schizophrenia. If you know anything about brains, you've heard of neurons. Those are the cells that have long been seen as central to virtually everything your brain thinks, feels, and does. But neurons represent only 10% of your brain cells. What does the other 90% do? Until recently, scientists didn't have a clue. Now, they're discovering the real function of those long-negl...
Lessing Yearbook / Jahrbuch XLVII, 2020
Das Lessing Yearbook/Jahrbuch 2020 enthält Beiträge zu Lessings Aristoteles-Lektüre, zum Drama "Philotas" im Kontext des Siebenjährigen Krieges, zum Spiel-Begriff und zur Toleranz-Thematik in "Nathan der Weise", zu Lessings nachgelassenen Blättern zu "Nathan" und zur Rezeption von Lessings Dramen in Amsterdam. Außerdem enthält der Band Aufsätze zur Gefühlsthematik in Joachim Wilhelm von Brawes Drama "Der Freygeist", zur Rolle des Apostels Thomas in Klopstocks "Messias" und zur kognitiven Narratologie in Karl Philipp Moritz "Reisen eines Deutschen in England". Abschließend bietet der Band einen Tagungsbericht zur digitalen Erarbeitung der Texte Lessings.
Neuroacanthocytosis Syndromes
Neuroacanthocytosis Syndromes is the first comprehensive review of a field that has not yet received the attention it deserves. Affecting the brain as well as the circulating red cells, these multi-system disorders in the past had often been mistaken for Huntington's disease. Recent breakthroughs have now identified the molecular basis of several of these. This volume grew out of the first international scientific meeting ever devoted to neuroacanthocytosis and provides in-depth information about the state of the art. Its thirty chapters were written by the leading authorities in the field to cover the clinical as well as the basic science perspective, including not only molecular genetics but also experimental pharmacology and cell membrane biology, among others. The book vehemently poses the question of how the membrane deformation of circulating red blood cells relates to degeneration of nerve cells in the brain, the basal ganglia, in particular. It provides a wealth of data that will help to solve an intriguing puzzle and ease the suffering of those affected by one of the neuroacanthocytosis syndromes.
