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Endoplasmic Reticulum and Its Role in Tumor Immunity
The endoplasmic reticulum (ER) is an organelle crucial to many cellular functions and processes, including the mounting of T-cell immune responses. Indeed, the ER has a well-established central role in anti-tumor immunity. Perhaps best characterized is the role of the ER in the processing of antigen peptides and the subsequent peptide assembly into MHC class I and II molecules. Such MHC/tumor-derived peptide complexes are pivotal for the correct recognition of altered self or viral peptides and the subsequent clonal expansion of tumor-reactive T-cells. In line with the role of the ER in immunity, tumor-associated mutations in ER proteins, as well as ER protein content and localization can ha...
Cell Biology by the Numbers
A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid
Peroxiporins
To produce energy, aerobic organisms transform oxygen molecules into water. This reductive mechanism yields toxic radical intermediates, collectively known as reactive oxygen species (ROS). Paradoxically, these physiological processes entail the production of potentially damaging species. Evolution has turned this apparent disadvantage into an opportunity for transmitting information. As a result, redox signaling within the cell is an efficient exquisitely organized process. A key element for its regulation is the physical separation of sources and targets into different cell compartments. Peroxiporins, H2O2 transporting proteins spanning biological membranes, distribute the signal from emit...
Animal Electricity
Animal electricity -- A world of cells, molecules, and atoms -- The animal battery -- Hodgkin and Huxley before the war -- The mystery of nerve conduction explained -- Heart to heart -- Nerve to muscle -- Use it or lose it -- Broadcasting in the volume conductor -- The bionic century
Organelle Contact Sites
This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neuro...
Calcium Signaling
Calcium signaling contains a unique selection of chapters that cover a wide range of contemporary topics in this ubiquitous and diverse system of cell signaling. This book has the flavor of a primary text book, but it is much more than that. It covers topics ranging from the fundamental aspects of calcium signaling to its clinical implications, in a thoughtful and comprehensive way. It discusses cutting edge researches, and critical issues at depth, and it presents many testable hypotheses for future research. It includes the theoretical and the methodological topics as well as topics related to mathematical modeling, and simulations. If you want to read about calcium signaling in different mammalian cells, oocytes, Zebrafishes, and even in plants, in one and the same book, then this book will not disappoint you. From the beginners to the experts in the field of calcium signaling, everybody will find something useful in this very timely book.
Fist from the Sky
- Fascinating look from the Japanese side at Pearl Harbor and the Battle of Midway - Fully authorized account including contemporary interviews with those that flew with Lt. Cdr. Egusa Lieutenant Commander Takashige Egusa was one of the Imperial Japanese Navy's most skillful and influential dive-bomber pilots. He led an attack force against Pearl Harbor, calmly circling his special flame-red Aichi dive bomber before selecting his target. Assaults on the deadly gun batteries of Wake Island followed, as well as air support for the invasion of Ambon. Badly burned at Midway, Egusa returned to duty, only to be killed on his final mission. As one Japanese officer said, "He was the 'God of Dive-Bombing.'" Fully placed in historical context and backed by a wealth of detail from archives, family records, photographs, and memories of contemporaries, the full story of Egusa's bravery, leadership qualities, and illustrious career comes to life.
