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MERS-CoV
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic coronavirus. First identified in 2012, MERS-CoV has caused over 2460 infections and a fatality rate of about 35% in humans. Similar to severe acute respiratory syndrome coronavirus (SARS-CoV), MERS-CoV likely originated from bats; however, different from SARS-CoV, which potentially utilized palm civets as its intermediate hosts, MERS-CoV likely transmits to humans through dromedary camels. Animal models, such as humanized mice and nonhuman primates, have been developed for studying MERS-CoV infection. Currently, there are no vaccines and therapeutics approved for the prevention and treatment of MERS-CoV infection...
Novel Diagnostic and Therapeutic Strategies in the Management of Cerebral Gliomas
Cerebral gliomas account for 45% of all primary central nervous system (CNS) tumors. The median survival after the initial diagnosis of glioblastoma (GBM) is only 15 months, and less than 10% of patients survive three years post-diagnosis. Surgical treatment followed by adjuvant therapies such as radiotherapy and chemotherapy represents the classical strategy in glioma management. The revised WHO 2016 classification now distinguishes the oligodendrogliomas with 1p19q codeletion and IDH mutation from the astrocytomas with or without IDH mutations, thereby creating homogenous and pathologically distinct subgroups. While the status of gene expression and mutations define components of GBM subtypes, it was also found that response to therapies was different for each subtype, suggesting that personalized treatment based on genomic alterations could lead to a more favorable outcome for this disease.
Single-Domain Antibodies: Biology, Engineering and Emerging Applications
Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics.
Next-Generation Sequencing of Human Antibody Repertoires for Exploring B-cell Landscape, Antibody Discovery and Vaccine Development
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Antivirals for Emerging Viruses: Vaccines and Therapeutics
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Virus Entry Inhibitors
This book focuses on the important discoveries of the small molecule-, peptide-, and protein-based virus entry inhibitors and discusses advance of the development of different type of virus entry inhibitors as a novel class of antiviral drugs for treatment and prevention of viral infection. It includes entry inhibitors of HIV,HeV, NiV, RSV, EBOV, HCoV, HBV, HCV, HDV, HPV, flavivirus and influenza virus, so on. This book aims at providing an updated knowledge on virus entry inhibitors.
Kerang Pokea sebagai Nutraceutical dan Pelestariannya
Buku yang berjudul Kerang Pokea sebagai Nutraceutical dan Pelestariannya merupakan karya dari Dr. Sri Anggarini Rasyid, S.Si., M.Si., dkk. Buku ini menguraikan manfaat kerang pokea, ekstrak kerang pokea dan kandungan untuk pencegahan penyebaran sel kanker, serta potensi kerang pokea sebagai imunostimulan dan antiproliferasi sel kanker secara in vitro dan in vivo pada mencit BALB/c. Selain itu, mengingat banyaknya manfaat yang diperoleh dari kerang pokea, buku ini juga memfokuskan pembahasan pada pentingnya upaya pelestarian kerang pokea, yang diharapkan dapat menumbuhkan kesadaran bersama untuk menjaga populasi kerang pokea. Buku ini terdiri dari beberapa pembahasan, diantaranya: · Kerang P...
Nutrition and Sustainable Development Goal 14: Life Below Water
Building on the Millennium Development Goals, the UN Sustainable Development Goals (SDGs) are the cornerstone of the 2030 Agenda for Sustainable Development, billed by the UN as “an agenda of unprecedented scope and significance.” These seventeen goals are conceived as integrated, indivisible, and as balancing the economic, social and environmental dimensions of sustainable development. To be achieved by 2030, the goals are organized around five core pillars: people, planet, prosperity, peace and partnership. As a member of the SDGs Publishers Compact, Frontiers is committed to advocating the themes represented by the SDGs and accelerating progress to achieve them. Nutrition sits at the ...
