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A Reciprocal Regulation of Spermidine and Autophagy in Podocytes Maintains the Filtration Barrier
Abstract: Podocyte maintenance and stress resistance are exquisitely based on high basal rates of autophagy making these cells a unique model to unravel mechanisms of autophagy regulation. Polyamines have key cellular functions such as proliferation, nucleic acid biosynthesis and autophagy. Here we test whether endogenous spermidine signaling is a driver of basal and dynamic autophagy in podocytes by using genetic and pharmacologic approaches to interfere with different steps of polyamine metabolism. Translational studies revealed altered spermidine signaling in focal segmental glomerulosclerosis in vivo and in vitro. Exogenous spermidine supplementation emerged as new treatment strategy by ...
Impact of Diabetic Stress Conditions on Renal Cell Metabolome
Abstract: Diabetic kidney disease is a major complication in diabetes mellitus, and the most common reason for end-stage renal disease. Patients suffering from diabetes mellitus encounter glomerular damage by basement membrane thickening, and develop albuminuria. Subsequently, albuminuria can deteriorate the tubular function and impair the renal outcome. The impact of diabetic stress conditions on the metabolome was investigated by untargeted gas chromatography-mass spectrometry (GC-MS) analyses. The results were validated by qPCR analyses. In total, four cell lines were tested, representing the glomerulus, proximal nephron tubule, and collecting duct. Both murine and human cell lines were u...
Shipton and Tilman
Using unpublished diaries, Jim Perrin tells the story of the greatest exploring partnership in British history. In the 1930s Tilman and the younger Shipton pioneered many routes in Africa and the Himalayas and found the key to unlocking Everest. They crossed Africa by bicycle, explored China with Spender and Auden, journeyed down the Oxus River to its source and, with no support, opened up much of the Nepalese Himalaya.
The Curious Incident of the Dog in the Night-Time
A bestselling modern classic—both poignant and funny—narrated by a fifteen year old autistic savant obsessed with Sherlock Holmes, this dazzling novel weaves together an old-fashioned mystery, a contemporary coming-of-age story, and a fascinating excursion into a mind incapable of processing emotions. Christopher John Francis Boone knows all the countries of the world and their capitals and every prime number up to 7,057. Although gifted with a superbly logical brain, Christopher is autistic. Everyday interactions and admonishments have little meaning for him. At fifteen, Christopher’s carefully constructed world falls apart when he finds his neighbour’s dog Wellington impaled on a g...
Germany
From Neil MacGregor, the author of A History of the World in 100 Objects, this is a view of Germany like no other Today, as the dominant economic force in Europe, Germany looms as large as ever over world affairs. But how much do we really understand about it, and how do its people understand themselves? In this enthralling new book, Neil MacGregor guides us through the complex history, culture and identity of this most mercurial of countries by telling the stories behind 30 objects in his uniquely magical way. Beginning with the fifteenth-century invention of the Gutenberg press, MacGregor ventures beyond the usual sticking point of the Second World War to get to the heart of a nation that has given us Luther and Hitler, the Beetle and Brecht - and remade our world again and again. This is a view of Germany like no other. Neil MacGregor has been Director of the British Museum since August 2002. He was Director of the National Gallery in London from 1987 to 2002. His celebrated books include A History of the World in 100 Objects, now translated into more than a dozen languages and one of the top-selling titles ever published by Penguin Press, and Shakespeare's Restless World.
