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Sobotta Anatomy Coloring Book ENGLISCH/LATEIN
The Sobotta Coloring Book – for understanding and learning anatomy The Sobotta Coloring Book offers another excellent way to study anatomy, perfectly suited to all those who are looking for an alternative to learning from textbooks. Dealing with the most important subjects in anatomy, the texts and the simple drawings designed to be colored-in help to understand and revise the most important aspects of human anatomy. This turns the book into something special: the pictures show the basic anatomical details and the accompanying texts explain the most important aspects of the structures. By actively interacting with the book through coloring-in, the content becomes deeply ingrained in the memory. The Sobotta Coloring Book provides: - basic anatomical details in over 100 sections, using pictures and text - concise accompanying texts for each picture, highlighting important details - clinical references, pointing out their practical relevance - sketches of sectional planes and perspectives which help with orientation - English - Latin Nomenclature
A Multi-layered Quantitative in Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes
Abstract: Damage to and loss of glomerular podocytes has been identified as the culprit lesion in progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with mRNA sequencing, bioinformatics, and hypothesis-driven studies to provide a comprehensive and quantitative map of mammalian podocytes that identifies unanticipated signaling pathways. Comparison of the in vivo datasets with proteomics data from podocyte cell cultures showed a limited value of available cell culture models. Moreover, in vivo stable isotope labeling by amino acids uncovered surprisingly rapid synthesis of mitochondrial proteins under steady-state conditions that was perturbed under autophagy-deficient, disease-susceptible conditions. Integration of acquired omics dimensions suggested FARP1 as a candidate essential for podocyte function, which could be substantiated by genetic analysis in humans and knockdown experiments in zebrafish. This work exemplifies how the integration of multi-omics datasets can identify a framework of cell-type-specific features relevant for organ health and disease
On oder off
Gerade hatte er eine attraktive neue Stelle als Arzt und Wissenschaftler am Universitätsklinikum Hamburg angetreten, als sich herausstellt, dass seine chronischen Nackenschmerzen nicht harmlos, sondern ein erstes Symptom des M. Parkinson sind. Ein Schicksalsschlag, doch er hat Glück, in den nächsten fünf Jahren lässt ihn die Erkrankung in Ruhe. Aber dann verändert sich alles innerhalb einer Woche. Eben noch voll berufstätig und mitten im Leben, verschlechtert sich nach einer Grippe sein Parkinson radikal. Er wird zum Pflegefall und ist an den Rollstuhl gefesselt. In seinem Buch beschreibt Oliver Kretz einerseits sehr ernsthaft und emotional, aber auch humorvoll und amüsant, seinen mühsamen und oft hoffnungslos erscheinenden Weg zurück ins Leben. Sein langer Aufenthalt in einer Rehaklinik ist aber auch voll von unfreiwillig lustigen und erfüllenden Momenten und endet unerwartet positiv.
Cilia-localized LKB1 Regulates Chemokine Signaling, Macrophage Recruitment, and Tissue Homeostasis in the Kidney
Abstract: Polycystic kidney disease (PKD) and other renal ciliopathies are characterized by cysts, inflammation, and fibrosis. Cilia function as signaling centers, but a molecular link to inflammation in the kidney has not been established. Here, we show that cilia in renal epithelia activate chemokine signaling to recruit inflammatory cells. We identify a complex of the ciliary kinase LKB1 and several ciliopathy-related proteins including NPHP1 and PKD1. At homeostasis, this ciliary module suppresses expression of the chemokine CCL2 in tubular epithelial cells. Deletion of LKB1 or PKD1 in mouse renal tubules elevates CCL2 expression in a cell-autonomous manner and results in peritubular accumulation of CCR2+ mononuclear phagocytes, promoting a ciliopathy phenotype. Our findings establish an epithelial organelle, the cilium, as a gatekeeper of tissue immune cell numbers. This represents an unexpected disease mechanism for renal ciliopathies and establishes a new model for how epithelial cells regulate immune cells to affect tissue homeostasis
A YAP/TAZ-ARHGAP29-RhoA Signaling Axis Regulates Podocyte Protrusions and Integrin Adhesions
Abstract: Glomerular disease due to podocyte malfunction is a major factor in the pathogenesis of chronic kidney disease. Identification of podocyte-specific signaling pathways is therefore a prerequisite to characterizing relevant disease pathways and developing novel treatment approaches. Here, we employed loss of function studies for EPB41L5 (Yurt) as a central podocyte gene to generate a cell type-specific disease model. Loss of Yurt in fly nephrocytes caused protein uptake and slit diaphragm defects. Transcriptomic and proteomic analysis of human EPB41L5 knockout podocytes demonstrated impaired mechanotransduction via the YAP/TAZ signaling pathway. Further analysis of specific inhibitio...
Sobotta-Malbuch
Jeder Student kennt das: Gerade eben schien die Anatomie beim Lernen ganz einfach, doch was weiß man noch, wenn das Lehrbuch zugeklappt ist? Wer sich langfristig einprägen will, wie anatomische Strukturen zueinander liegen, der sollte zur Abwechslung einmal selbst den Buntstift und das Sobotta Malbuch in die Hand nehmen: Einfache Schemazeichnungen nach Abbildungen aus dem Sobotta Atlas stellen die wesentlichen Details übersichtlich dar und bieten Platz zum Ausmalen - so bleibt Anatomie hängen! -Über 100 Lerneinheiten aus Bild und Text -Knappe Begleittexte leiten durch jedes Bild und weisen auf wichtige Details hin -Klinische Hinweise stellen praktischen Bezug her -Skizzen zu Schnittebenen und Blickrichtungen helfen bei der Orientierung
