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Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus MiR-UL112-5p-mediated Immunoevasion
Abstract: Herein, we demonstrate that HCMV miR-UL112-5p targets ERAP1, thereby inhibiting the processing and presentation of the HCMV pp65495-503 peptide to specific CTLs. In addition, we show that the rs17481334 G variant, naturally occurring in the ERAP1 3′ UTR, preserves ERAP1 from miR-UL112-5p-mediated degradation. Specifically, HCMV miR-UL112-5p binds the 3′ UTR of ERAP1 A variant, but not the 3′ UTR of ERAP1 G variant, and, accordingly, ERAP1 expression is reduced both at RNA and protein levels only in human fibroblasts homozygous for the A variant. Consistently, HCMV-infected GG fibroblasts were more efficient in trimming viral antigens and being lysed by HCMV-peptide-specific CTLs. Notably, a significantly decreased HCMV seropositivity was detected among GG individuals suffering from multiple sclerosis, a disease model in which HCMV is negatively associated with adult-onset disorder. Overall, our results identify a resistance mechanism to HCMV miR-UL112-5p-based immune evasion strategy with potential implications for individual susceptibility to infection and other diseases
Rock Engineering and Rock Mechanics: Structures in and on Rock Masses
Rock Engineering and Rock Mechanics: Structures in and on Rock Masses covers the most important topics and state-of-the-art in the area of rock mechanics, with an emphasis on structures in and on rock masses. The 255 contributions (including 6 keynote lectures) from the 2014 ISRM European Rock Mechanics Symposium (EUROCK 2014, Vigo, Spain, 27-29 Ma
Narrative, Interrupted
Recent postclassical narratology has constructed top-down reading models that often remain blind to the frame-breaking potential of individual literary narratives. Narrative, Interrupted goes beyond the macro framing typical of postclassical narratology and sets out to sketch approaches more sensitive to generic specificities, disturbing details and authorial interference. Unlike the mainstream cognitive approaches or even the emergent unnatural narratology, the articles collected here explore the artifice involved in presenting something ordinary and realistic in literature. The first section of the book deals with anti-dynamic elements such as dialogue, details, private events and literary...
Rock Mechanics for Natural Resources and Infrastructure Development - Full Papers
Rock Mechanics for Natural Resources and Infrastructure Development contains the proceedings of the 14th ISRM International Congress (ISRM 2019, Foz do Iguaçu, Brazil, 13-19 September 2019). Starting in 1966 in Lisbon, Portugal, the International Society for Rock Mechanics and Rock Engineering (ISRM) holds its Congress every four years. At this 14th occasion, the Congress brings together researchers, professors, engineers and students around contemporary themes relevant to rock mechanics and rock engineering. Rock Mechanics for Natural Resources and Infrastructure Development contains 7 Keynote Lectures and 449 papers in ten chapters, covering topics ranging from fundamental research in roc...
Dynamics in GIscience
This book is intended for researchers, practitioners and students who are interested in the current trends and want to make their GI applications and research dynamic. Time is the key element of contemporary GIS: mobile and wearable electronics, sensor networks, UAVs and other mobile snoopers, the IoT and many other resources produce a massive amount of data every minute, which is naturally located in space as well as in time. Time series data is transformed into almost (from the human perspective) continuous data streams, which require changes to the concept of spatial data recording, storage and manipulation. This book collects the latest innovative research presented at the GIS Ostrava 2017 conference held in 2017 in Ostrava, Czech Republic, under the auspices of EuroSDR and EuroGEO. The accepted papers cover various aspects of dynamics in GIscience, including spatiotemporal data analysis and modelling; spatial mobility data and trajectories; real-time geodata and real-time applications; dynamics in land use, land cover and urban development; visualisation of dynamics; open spatiotemporal data; crowdsourcing for spatiotemporal data and big spatiotemporal data.
Radio Network Planning and Optimisation for UMTS
Radio Network Planning and Optimisation for UMTS, Second Edition, is a comprehensive and fully updated introduction to WCDMA radio access technology used in UMTS, featuring new content on key developments. Written by leading experts at Nokia, the first edition quickly established itself as a best-selling and highly respected book on how to dimension, plan and optimise UMTS networks. This valuable text examines current and future radio network management issues and their impact on network performance as well as the relevant capacity and coverage enhancement methods. In addition to coverage of WCDMA radio access technology used in UMTS, and the planning and optimisation of such a system, the s...
