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This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology. The book also covers the design, synthesis and biological validation of epigenetic chemical modulators, which can be useful as novel chemotherapeutic agents. Particular attention is given to the chemical mechanisms of action of these molecules and to the drug discovery prose which allows their identification. This book will appeal to students who want to know the extensive progresses made by epigenetics (targets and modulators) in the last years from the beginning, and to specialized scientists who need an instrument to quickly search and check historical and/or updated notices about epigenetics.
This book delineates the contours of molecular and structural archaeology as an emergent interdisciplinary field based on structural analysis at the molecular level and examines novel methodologies to reconstruct the synthesis and long-term transformation of materials used in antiquity. The focus of this volume is on cosmetic and therapeutic materials.
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This book takes a close look at how the sport industry has been impacted by the global Coronavirus pandemic, as entire seasons have been cut short, events have been cancelled, athletes have been infected, and sport studies programs have moved online. Crucially, the book also asks how the industry might move forward. With contributions from sport studies researchers across the world, the book offers commentaries, cases, and informed analysis across a wide range of topics and practical areas within sport business and management, from crisis communication and marketing to event management and finance. While Covid-19 will inevitably cast a long shadow over sport for years to come, and although the situation is fast-evolving and the future is uncertain, this book offers some important early perspectives and reflections that will inform debate and influence policy and practice. A timely addition to the body of knowledge regarding the pandemic, this is an important resource for researchers, students, practitioners, the media, policy-makers, and anybody who cares about the future of sport.
Scintillation Dosimetry delivers a comprehensive introduction to plastic scintillation dosimetry, covering everything from basic radiation dosimetry concepts to plastic scintillating fiber optics. Comprised of chapters authored by leading experts in the medical physics community, the book: Discusses a broad range of technical implementations, from point source dosimetry scaling to 3D-volumetric and 4D-scintillation dosimetry Addresses a wide scope of clinical applications, from machine quality assurance to small-field and in vivo dosimetry Examines related optical techniques, such as optically stimulated luminescence (OSL) or Čerenkov luminescence Thus, Scintillation Dosimetry provides an authoritative reference for detailed, state-of-the-art information on plastic scintillation dosimetry and its use in the field of radiation dosimetry.
This atlas illustrates the latest available data on the cancer epidemic, showing causes, stages of development, and prevalence rates of different types of cancers by gender, income group, and region. It also examines the cost of the disease, both in terms of health care and commercial interests, and the steps being taken to curb the epidemic, from research and screening to cancer management programs and health education.