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Single-cell Transcriptomics Reveals Distinct Inflammation-induced Microglia Signatures
Abstract: Microglia are specialized parenchymal-resident phagocytes of the central nervous system (CNS) that actively support, defend and modulate the neural environment. Dysfunctional microglial responses are thought to worsen CNS diseases; nevertheless, their impact during neuroinflammatory processes remains largely obscure. Here, using a combination of single-cell RNA sequencing and multicolour flow cytometry, we comprehensively profile microglia in the brain of lipopolysaccharide (LPS)-injected mice. By excluding the contribution of other immune CNS-resident and peripheral cells, we show that microglia isolated from LPS-injected mice display a global downregulation of their homeostatic signature together with an upregulation of inflammatory genes. Notably, we identify distinct microglial activated profiles under inflammatory conditions, which greatly differ from neurodegenerative disease-associated profiles. These results provide insights into microglial heterogeneity and establish a resource for the identification of specific phenotypes in CNS disorders, such as neuroinflammatory and neurodegenerative diseases
Technology, Management and the Evangelical Church
This book explores the technological innovations and management practices of evangelical Christian religions. Beginning from the late 19th century, the author examines the evangelical church's increasing appropriation of business practices from the secular world as solutions to organizational problems. He notes especially the importance of the church growth movement and the formation of church networks. Particular attention is paid to the history of evangelical uses of computer technology, including connections the Christian Right has made within Silicon Valley. Most significantly, this book offers one of the first academic explorations of the use of cybernetics, systems theory and complexity theory by evangelical leaders and management theorists.
The Frontman
Celebrity philanthropy comes in many guises, but no single figure better encapsulates its delusions, pretensions and wrongheadedness than U2’s iconic frontman, Bono—a fact neither sunglasses nor leather pants can hide. More than a mere philanthropist—indeed, he lags behind many of his peers when it comes to parting with his own money—Bono is better described as an advocate, one who has become an unwitting symbol of a complacent wealthy Western elite. The Frontman reveals how Bono moved his investments to Amsterdam to evade Irish taxes; his paternalistic and often bullying advocacy of neoliberal solutions in Africa; his multinational business interests; and his hobnobbing with Paul Wolfowitz and shock-doctrine economist Jeffrey Sachs. Carefully dissecting the rhetoric and actions of Bono the political operator, The Frontman shows him to be an ambassador for imperial exploitation, a man who has turned his attention to a world of savage injustice, inequality and exploitation—and helped make it worse.
Billboard
In its 114th year, Billboard remains the world's premier weekly music publication and a diverse digital, events, brand, content and data licensing platform. Billboard publishes the most trusted charts and offers unrivaled reporting about the latest music, video, gaming, media, digital and mobile entertainment issues and trends.
SPIN
From the concert stage to the dressing room, from the recording studio to the digital realm, SPIN surveys the modern musical landscape and the culture around it with authoritative reporting, provocative interviews, and a discerning critical ear. With dynamic photography, bold graphic design, and informed irreverence, the pages of SPIN pulsate with the energy of today's most innovative sounds. Whether covering what's new or what's next, SPIN is your monthly VIP pass to all that rocks.
Christianity and Controversies over Homosexuality in Contemporary Africa
Issues of homosexuality are the subject of public and political controversy in many African societies today. Frequently, these controversies receive widespread attention both locally and globally, such as with the Anti-Homosexuality Bill in Uganda. In the international media, these cases tend to be presented as revealing a deeply-rooted homophobia in Africa fuelled by religious and cultural traditions. But so far little energy is expended in understanding these controversies in all their complexity and the critical role religion plays in them. Complementing the companion volume, Public Religion and the Politics of Homosexuality in Africa, this book investigates Christian politics and discour...
Seeking Sanctuary
Seeking Sanctuary brings together life stories from LGBT migrants living in Johannesburg and their battle to reconcile faith with their sexual identity. The narratives reveal the complex interplay between homophobia and xenophobia; the fight for sexual and gender rights; and how faith-based organisations can direct social change.
Public International Law and the Regulation of Diplomatic Immunity in the Fight Against Corruption
Public International Law and the Regulation of Diplomatic Immunity in the Fight against Corruptionby Kenneth K Mwenda2011ISBN: 978-0-9869857-9-9Pages: 212Print version: AvailableElectronic version: Free PDF available.
