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This volume focuses on RNAs interacting with chromatin and their function. Chapters guide readers through transcription, splicing, non-coding RNA function and manipulation of gene expression. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, RNA-Chromatin Interactions: Methods and Protocols aims to be a starting-point to expand researchers experimental approaches towards the numerous outstanding questions in this new and expanding field.
Biology, medicine and biochemistry have become data-centric fields for which Deep Learning methods are delivering groundbreaking results. Addressing high impact challenges, Deep Learning in Biology and Medicine provides an accessible and organic collection of Deep Learning essays on bioinformatics and medicine. It caters for a wide readership, ranging from machine learning practitioners and data scientists seeking methodological knowledge to address biomedical applications, to life science specialists in search of a gentle reference for advanced data analytics.With contributions from internationally renowned experts, the book covers foundational methodologies in a wide spectrum of life scien...
This volume presents a comprehensive exposition of both the prehistory and medieval history of the whole of Scandinavia. The first part of the volume surveys the prehistoric and historic Scandinavian landscape and its natural resources, and tells how man took possession of this landscape, adapting culturally to changing natural conditions and developing various types of community throughout the Stone, Bronze and Iron Ages. The rest - and most substantial part of the volume - deals with the history of Scandinavia from the Viking Age to the end of the Scandinavian Middle Ages (c. 1520). The external Viking expansion opened Scandinavia to European influence to a hitherto unknown degree. A Christian church organisation was established, the first towns came into being, and the unification of the three medieval kingdoms of Scandinavia began, coinciding with the formation of the unique Icelandic 'Free State'.
Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to...
The book discusses the challenges war and conflict reporting face when confronted with major security leaks through WikiLeaks and the classified information revealed by Edward Snowden. Theoretically, the findings are related to the theories of threat society, new wars and risk-transfer warfare as well as to Johan Galtung"s theory of war and peace journalism. Analyses are inspired by critical discourse analysis as elaborated in Norman Fairclough"s and Ruth Wodak"s works.
Sosdala is a famous name in European archaeology of the Migration Period. But the fame of the name has thrown the find itself in deep shade. This is surprising since it contains mounts from an exquisitely decorated parade bridle, the closest parallels to which are found in Austria, Poland, Romania and Ukraine. The craftsmanship equals the best Late Roman metalwork. The content of the Sosdala finds reveal that Scandinavians were involved in the turmoil when the Late Roman Empire disintegrated. The context, depositions of dismantled horse tack in gravel ridges, is explainable with reference to Nomadic funerary rituals. Based on new scholarly studies and scientific analyses a European team of scholars places Sosdala in its European setting. The book is concluded by full catalogues of three finds of horse tack from Sosdala and Fulltofta. The papers in English have resumes and captions in Russian.
"During the Late Bronze Age, the Iron Age and early medieval period (c. 600 BC-AD 1250) settlement at Vik in the Ørland peninsula emerged, flourished, vanished and emerged anew. Local landscape and vegetation development, cross-regional cultural developments and global climatic events were of great significance to the farmer-fisher communities at Vik throughout these periods. In this book, results from the 2014-2016 archaeological excavations at Ørland main air base have been refined and developed. The 13 papers deal with landscape, vegetation and environmental aspects related to the excavated settlement, as well as the spatial and social organization of the built environment. Building traditions, disposal practices, the form and representation of everyday objects, subsistence and landscape use are central to the discussions." This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Come join the adventure in Symbaroum, the acclaimed Swedish roleplaying game! Explore the vast Forest of Davokar in the hunt for treasure, lost wisdom and eternal fame. Visit the barbarian clans to trade or to plunder their treasuries. Establish a base of power among princes, guilds or rebellious refugees in the capital city of Yndaros. Or survive encounters with Arch Trolls, dark-minded Blight Beasts and undead warlords. But whatever you do, never ignore the warnings spoken by the wardens of the forest: tread carefully and do not disturb the ruins of old, for the dark deep of Davokar is about to awaken. Made in Sweden