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Myelodysplastic Syndromes
  • Language: en
  • Pages: 245

Myelodysplastic Syndromes

The diagnosis of myelodysplastic syndromes (MDS), a heterogeneous group of clonal hematopoietic disorders, is being made with increasing frequency over the past decade owing to increased recognition, improved understanding, and an aging population. This book, completely updated since the first edition, summarizes in a concise and focused way the current knowledge of all aspects of MDS. Clinical presentation, etiology, epidemiology, molecular biology, classification, and staging are all discussed. Clear guidance is provided on diagnosis and differential diagnosis, and treatment strategies are explained in detail, including administration of hematopoietic growth factors, biologically based treatment, hematopoietic stem cell transplantation, and supportive care. Additional chapter is devoted to MDS in children. This practically oriented book will be of value to a broad spectrum of students and practitioners in the field.

Targeted Therapy of Acute Myeloid Leukemia
  • Language: en
  • Pages: 826

Targeted Therapy of Acute Myeloid Leukemia

  • Type: Book
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  • Published: 2014-11-20
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  • Publisher: Springer

This book provides an unprecedented overview of "Targeted Therapies" for acute myeloid leukemias. It aims at an almost comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Paired and authoritative chapters by leading research scientists and clinicians explain basic concepts and clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML, the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53 and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. ...

Encyclopedia of Molecular Mechanisms of Disease
  • Language: en
  • Pages: 2348

Encyclopedia of Molecular Mechanisms of Disease

This comprehensive encyclopedia supplies the reader with concise information on the molecular pathophysiology of disease. Entries include defined diseases (such as Parkinson's disease) as well as pathophysiological entities (such as tremor). The 1,200 essays are brilliantly structured to allow rapid retrieval of the desired information. For more detailed reading, each entry is followed by up to five references. Individual entries are written by leading experts in the respective area of research to ensure state-of-the-art descriptions of the mechanisms involved. It is an invaluable companion for clinicians and scientists in all medical disciplines.

Leukemias
  • Language: en
  • Pages: 460

Leukemias

Edited by experts from one of the world’s largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials. Topics include: Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors) Ras inhibitors Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors) Lenalidomide analogs New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib) New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40) Thrombopoietic agents Leukemias: Principles and Practice of Therapy Includes practical information to guide you in challenging situations, such as treatment of elderly patients, pregnancy, relapsed and refractory disease Incorporates chapters on supportive care and pharmacologic information about the most frequently used drugs in this area

Kapesní atlas hematologie
  • Language: cs
  • Pages: 231

Kapesní atlas hematologie

Skvělá kniha, která je určena mladým lékařům, hematologům, internistům, laborantům ale i medikům. Obsahuje všechna hematologická onemocnění s jejich typickými nálezy, poučení k typickým znakům a didaktické návody k vyobrazením. Čtenář v ní najde praktické návody, jak odlišit ještě „normální“ od patologického a obeznámí se i s technikami a technickými metodami vyšetřování (např. barvením, cyto-chemií, imuno-cytologií apod.). Barevná, bohatě ilustrovaná publikace obsahuje na 300 obrázků a tabulek! Přeloženo z německého originálu „Taschematlas Hämatologie“, který vydalo v roce 2012 nakladatelství Thieme Verlag v již 6., přepracovaném vydání.

Economic Opportunities of Climate Action
  • Language: en

Economic Opportunities of Climate Action

  • Type: Book
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  • Published: 2019
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  • Publisher: Unknown

Climate protection pays off! This is the central statement of the study "Economic opportunities through climate protection". The study examined which economic effects climate protection policy has had so far and which potentials will arise in the future. The results show: Climate protection goes hand in hand with innovation. Together with the necessary investments in renewable energies, energy efficiency, building refurbishment and climate-friendly mobility, it makes Germany fit for the future. Wages and gross domestic product are also rising in a world where the climate is being protected.

Who's who in Germany
  • Language: en
  • Pages: 1268

Who's who in Germany

  • Type: Book
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  • Published: 1988
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  • Publisher: Unknown

Vols. for 1956- include a separately paged section: Directory of organizations, associations and institutions.

Labordiagnostik in der Hämatologie
  • Language: de
  • Pages: 130

Labordiagnostik in der Hämatologie

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Öffentliche Erziehung im Strukturwandel
  • Language: de
  • Pages: 239

Öffentliche Erziehung im Strukturwandel

Die AutorInnen dieses Bandes gehen der Frage nach, wie eine komplexe, aufeinander abgestimmte öffentliche Erziehung der Heranwachsenden gestaltet werden kann und welche Reformschritte dafür notwendig sind. Es wird deutlich, dass der nachhaltige soziale Wandel auch die Bildung und Erziehung der Kinder und Jugendlichen schon jetzt vielfältig verändert hat. Die alten Dichotomien (private vs. öffentliche Erziehung, Kindergarten vs. Schule, Schule vs. Soziale Arbeit, Bildung vs. Ausbildung) werden zunehmend in Frage gestellt, ohne dass die neuen institutionellen und interaktiv-pädagogischen Konturen schon deutlich sind.

Morphologische Blutzelldifferenzierung
  • Language: de
  • Pages: 236

Morphologische Blutzelldifferenzierung

Der Stellenwert der konventionellen hämatologischen Morphologie ist trotz neuer apparativer, immunologischer, genetischer und molekularer Methoden unbestritten. Dieses Buch integriert neben der konventionellen auch die digitale bzw. computergestützte Mikroskopie, die Arbeitsabläufe zeitlich entlastet, Archivierung und digitale Weiterleitung von morphologischen Bildern sowie eine realistische Qualitätskontrolle in der Blutbilddifferenzierung ermöglicht. So sollte die morphologische Unterscheidung reaktiver und neoplastischer lymphatischer Zellen, die Erkennung einer Promyelozyteneukämie anhand der Granulierung und der typischen Kernkonfiguration der Blasten, die zweifelsfreie Identifizi...