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Cell Biology of the Major Histocompatibility Complex
Cell Biology of the Major Histocompatibility Complex documents the proceedings of a symposium on ""Cell Biology of the Major Histocompatibility Complex"" held at Arden House on the Harriman Campus of Columbia University from June 8 -10, 1984. The meeting was the ninth of the P & S Biomedical Sciences Symposia. The book is organized into five parts. Part I on the structure of MHC molecules includes papers on human histocompatibility antigens; the cloning of human MHC; and organization of the genes of the H-2 complex. Part II on alternate forms of MHC molecules includes studies on the expression of a secreted form of the MHC class I antigen and alternative splicing in the H-2 multigene family....
New Mechanisms for Tissue-Selective Estrogen-Free Contraception
Combined oral contraceptives are the most convenient and accepted method of hormonal contraception. Nevertheless, the medical community and consumers constantly demand innovation, additional benefits during use and lower hormonal load despite the high safety profile of available products. At the Ernst Schering Research Foundation Workshop 52, new perspectives and mechanisms for tissue-selective, estrogen-free contraception were discussed. The aim of the workshop was to bring together experts in the field of molecular and pharmacodynamic action of progestins with clinicians and medical experts to discuss potential medical endpoints, physiological reactions and (bio)marker useful describing the tissue selectivity and the contraceptive action of new progestins in different target organs. A major factor for successful realization of these new concepts is a deeper understanding of local pharmacological responses to progestins in general and to new progestins in particular.
Britain's Levantine Empire, 1914-1923
Britain's Levantine Empire, 1914-1923 explains the rise and decline and nature and extent of British military rule in the urban eastern Mediterranean during the course of the First World War and its aftermath. Combining novel case studies and theoretical approaches, the volume reveals the extent of military control that Britain established and anticipated maintaining in the post-Ottoman world, before a series of confrontations with nationalist and socialist anti-imperialists forced a new division of the eastern Mediterranean, still visible in the political borders of the present day. Britain's Levantine Empire, 1914-1923 tells this story through the eyes and ears of the British servicemen wh...
Dirty Drugs
Psychische Erkrankungen gehoren epidemiologisch weltweit zu den verbreitetsten Krankheitsrisiken. Psychopharmaka pragen unsere Gesellschaft starker, als uns dies bewusst ist. Gleichwohl ist der rechtliche Rahmen der psychopharmakologischen Forschung und Therapie fragmentiert sowie teils von vorrationalen Pfadabhangigkeiten gepragt. Die vorliegende Untersuchung geht von der Geschichte der wissenschaftlichen Psychopharmakologie sowie den neurochemischen Wirkungsmechanismen typischer Psychopharmaka aus. Klaus Ferdinand Garditz analysiert die wildwuchsigen Regelungsstrukturen und die damit verbundenen Wechselwirkungen zwischen Pharmakologie, Gesellschaft und Recht als institutionelle Herrschafts...
Beyond the Walled City
"Once one of the most important port cities in the New World, Havana was a model for the planning and construction of other colonial cities. This book tells the story of how Havana was conceived, built, and managed and explores the relationship between colonial empire and urbanization in the Americas. Guadalupe García shows how the policing of urban life and public space by imperial authorities from the sixteenth century onward was explicitly centered on politics of racial exclusion and social control. She illustrates the importance of colonial ideologies in the production of urban space and the centrality of race and racial exclusion as an organizing ideology of urban life in Havana. Beyond the Walled City connects colonial urban practices to contemporary debates on urbanization, the policing of public spaces, and the urban dislocation of black and ethnic populations across the region"--Provided by publisher.
New Approaches to Drug Discovery
This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase.
DUZ
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The City in the Ottoman Empire
The nexus of urban governance and human migration was a crucial feature in the modernisation of cities in the Ottoman Empire of the nineteenth century. This book connects these two concepts to examine the Ottoman city as a destination of human migration, throwing new light on the question of conviviality and cosmopolitanism from the perspective of the legal, administrative and political frameworks within which these occur. Focusing on groups of migrants with various ethnic, regional and professional backgrounds, the book juxtaposes the trajectories of these people with attempts by local administrations and the government to control their movements and settlements. By combining a perspective ...
Spaces of Conflict in Everyday Life
Conflicts are everyday situations and experiences with which people have to cope. Focusing on particularly conflict-prone parts of Asia, the contributions to this book analyze the dynamics of conflicts from the perspectives of the actors involved, and pay particular attention to aspects like mobilization, exclusion, segregation, the role of institutions and the construction of antagonistic identities. The book gathers case studies based on long-term fieldwork from conflicts in Kyrgyzstan, Afghanistan, Pakistan, and Kashmir.
