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Toll-like Receptors: Roles in Infection and Neuropathology
Mammalian Toll-like receptors (TLRs) were first identified in 1997 based on their homology with Drosophila Toll, which mediates innate immunity in the fly. In recent years, the number of studies describing TLR expression and function in the nervous system has been increasing steadily and expanding beyond their traditional roles in infectious diseases to neurodegenerative disorders and injury. Interest in the field serves as the impetus for this volume in the Current Topics in Microbiology and Immunology series entitled "Toll-like receptors: Roles in Infection and Neuropathology". The first five chapters highlight more traditional roles for TLRs in infectious diseases of the CNS. The second h...
Neuroinflammation and Neurodegeneration
State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.
Clinical Neuroimmunology
Clinical Neurimmunology is the major reference text in the field, providing broad and comprehensive coverage of the interaction between the nervous and immune systems in both normal and diseased states. Understanding this interaction is fundamental to developing therapeutic approaches to disease and injury of the nervous system that are currently only marginally amenable to therapy. Neuroimmunology is a well-recognised and growing specialty world wide, both at the basic science and clinical level. It is a fast moving field and this is the most up to date text available. Chapters are dedicated to the role of the immune system in disorders affecting both the central and peripheral nervous syst...
Meningitis
Examining meningitis mainly from a bacterial perspective, but also including an overview of viral, fungal and chronic meningitis, this book describes the anatomy of the meninges and clinical signs and symptoms of meningitis. Individual organisms that cause meningitis worldwide are dealt with in specific chapters, describing in detail how these pathogens interact with the human host at both a molecular and cellular level, providing a thorough understanding of bacterial virulence factors and host cell response.
Cytokines and the CNS
In Cytokines and the CNS, leading practicing physicians and scientists review the current status of cytokines, with an emphasis on their role in developmental and pathological processes in the central nervous system (CNS). They describe various cytokine families and their receptors, focusing on the delineation of known mechanisms by which ligand-receptor interactions mediate biological effects. The book also emphasizes interactions between cytokines and other biological regulators at the cellular and molecular level, and considers in detail tissue-specific effects exerted on CNS cells by cytokines. Cytokine regulation of CNS development also is discussed. With this background, Cytokines and ...
Cerebral Palsy
This edited book presents the latest information on epidemiology, pathophysiology, diagnosis, and some current topics covering all aspects of cerebral palsy. It offers a novel interpretation of a group of lifelong movement disorders, which now is an accepted notion that the causes of cerebral palsy are multifactorial rather than birth asphyxia. The book is organized into three parts, and it begins with illustrating the perspective of the disease. Then focuses on the relationship between clinical features of perinatal complications/events and cerebral palsy. The last part offers a hot topic of the prevention such as hypothermia, neuroprotection, and stem cell transfer. Since there is no cure ...
Neuroscience Letters
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