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Endothelial dysfunction is now regarded as an early marker of vascular disease and therefore an important target for therapeutic intervention and discovery of novel treatments. Ideal for both basic and clinical scientists, whether in industry or academia, and physicians, Vascular Endothelium in Human Physiology and Pathophysiology provides an up-to-date review of the vascular functions of the endothelium and its role in key areas of cardiovascular disease. It focuses on evidence from studies in humans.
This COMPSTAT 2002 book contains the Keynote, Invited, and Full Contributed papers presented in Berlin, August 2002. A companion volume including Short Communications and Posters is published on CD. The COMPSTAT 2002 is the 15th conference in a serie of biannual conferences with the objective to present the latest developments in Computational Statistics and is taking place from August 24th to August 28th, 2002. Previous COMPSTATs were in Vienna (1974), Berlin (1976), Leiden (1978), Edinburgh (1980), Toulouse (1982), Pra~ue (1984), Rome (1986), Copenhagen (1988), Dubrovnik (1990), Neuchatel (1992), Vienna (1994), Barcelona (1996), Bris tol (1998) and Utrecht (2000). COMPSTAT 2002 is organise...
Over the last three decades the process industries have grown very rapidly, with corresponding increases in the quantities of hazardous materials in process, storage or transport. Plants have become larger and are often situated in or close to densely populated areas. Increased hazard of loss of life or property is continually highlighted with incidents such as Flixborough, Bhopal, Chernobyl, Three Mile Island, the Phillips 66 incident, and Piper Alpha to name but a few. The field of Loss Prevention is, and continues to, be of supreme importance to countless companies, municipalities and governments around the world, because of the trend for processing plants to become larger and often be si...
In recent years, a wide variety of new chemicals have continued to be developed as a result of industrial development and associated anthropogenic activities. The microbial contaminants in the environment, more precisely, antibiotic-resistant genes/bacteria produced as a result of mutation due to antibacterial drugs, are also considered emerging contaminants and specifically called emerging microbial contaminants such as sapoviruses, Waddlia chondrophila and Streptococcus parauberis. Additionally, pharmaceuticals and personal care products are a diverse group of compounds that include ibuprofen, diclofenac, triclosan, antibiotics, anti-inflammatory agents, steroidal hormones and active ingre...
In recent years, there has been a lot of interest in using nanotechnology in medicine to diagnose and cure various infectious diseases. Although the precise mechanism of action is frequently challenged, many nanosized materials have been extensively explored for this purpose, using their innately unique features. Their functionality has also been enhanced by the addition of various coatings, such as those that increase chemical stability and stealth properties or contain targeting agents that lessen off-target effects while producing effective "smart" nanoplatforms for the early detection, treatment, and possibly resolution of diseases. This book aims to compile research and review articles that concentrate on the synthesis, characterization, and applications of nanomaterials, such as nanoparticles, with a focus on investigating novel ways to improve their properties and create new efficient diagnostic, therapeutic, or theranostic approaches with a clear understanding of how they work.
Structural heart disease encompasses a wide range of abnormalities involving noncoronary structures like the heart's valves, walls, and chambers. The last decade emphasized the burden of the disease and revolutionized the treatment strategies. The number of percutaneous structural heart interventions constantly increases worldwide. While some parts of the world acquire experience with various intervention treatments, techniques, and devices, others are paving their first steps. Complex Cases in Structural Heart Interventions provide a descriptive and highly illustrative insight into unique clinical situations managed by one of the world's most experienced and innovative teams. Each case study contains a clinical presentation, imaging analysis, procedural dilemmas, and resulting outcome. A detailed explanation of the technique used, key points and tips were highlighted, and a literature review covered broad knowledge on each topic. The authors shared their knowledge and distinctive solutions from over a decade of experience to ensure an educational adventure for the medical community and a roadmap for interventional heart teams.
This volume describes the most recent medical guidelines for perioperative management in arthroplasty with the aim of facilitating excellent control of bleeding/thrombosis, pain and infection. For each area – hemostasis control, pain control and infection control – hot topics of key practical importance are discussed and contrasting perspectives are presented on controversial issues, covering the views of different practitioners and specialties. Using the information contained in this book, the practitioner will be in an excellent position to meet the principal goals of perioperative medical management. The information provided will assist in the choice of a multimodal guideline that min...
Ecotoxicity and Human Health emphasizes the relationships between toxicity, ecological systems, and human health. It focuses on the extent and nature of hazardous waste sites and how their effects may be studied in humans and other systems, using in vitro models, biomarkers of cellular and molecular damage, and animal models. It also includes considerable information on bioremediation, legal and regulatory issues, public perceptions and societal responses, quantitative modeling and analysis, and international directives. One of the unique features of Ecotoxicity and Human Health is its coverage of the legislative actions that have occurred over the past two decades and which have most affected the issue of hazardous waste. The book discusses the Superfund Statute, the Resource Conservation and Recovery Act (RCRA), the Toxic Substances Control Act (TSCA), the Ocean Dumping Act of 1972, the Rio Conference, United Nations Declarations, EC Regulations and Directives, and selected state legislation.