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Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
Is your firm’s board creating value—or destroying it? Change is coming. Leadership at the top is being redefined as boards take a more active role in decisions that once belonged solely to the CEO. But for all the advantages of increased board engagement, it can create debilitating questions of authority and dangerous meddling in day-to-day operations. Directors need a new road map—for when to lead, when to partner, and when to stay out of the way. Boardroom veterans Ram Charan, Dennis Carey, and Michael Useem advocate this new governance model—a sharp departure from what has been demanded by governance activists, raters, and regulators—and reveal the emerging practices that are de...
This book explores the work of Sir John Tenniel, the artist who illustrated the first editions of Lewis Carroll's best-known works. Although Tenniel and Carroll parted ways after publication of Through the Looking-Glass, the artist's designs fixed in the public's mind images of Carroll's characters that thrive down to the present day.
A Grammar of Modern Indo-European is a complete reference guide to a living Indo-European language. It contains a comprehensive description of Proto-Indo-European grammar, and offers an analysis of the complexities of the prehistoric language and its reconstruction from its descendant languages. Written in a fresh and accessible style, and illustrated with maps, figures and tables, this book focusses on the real patterns of use of Late Indo-European. The book is well organised and is filled with full, clear explanations of areas of confusion and difficulty. It also contains an extensive English - Indo-European, Indo-European - English vocabulary, as well as detailed etymological notes, designed to provide readers with an easy access to the information they require.An essential reference source for the student of Indo-European as a learned and living language, this work will appeal to students of languages, classics, and the ancient world, as well as to general readers interested in the history of language, and in speaking the direct ancestor of the world's largest language family.
This revised edition of the popular reference and textbook outlines the historical developments in computing technology. It explains and describes historical aspects of calculation with an emphasis on the physical devices used in different times to aid people in their attempts at automating the process of arithmetic.
This volume provides reviews and details of the quality, safety and efficacy for some of the top-selling botanicals worldwide, including black cohosh, chamomile, comfrey, echinacea, garlic, ginkgo, ginseng, kava, milk thistle, St John's wort and valerian. The work was written based on a systematic review of the scientific literature from 1975-2000.;Each review includes a brief introduction, a section on quality including a definition of the crude drug, geographical distribution, and a listing of the major chemical constituents. The safety and efficacy sections summarize the medical uses, pharmacology, contraindications, warnings, precautions, adverse reactions, dose and dosage forms. The safety and efficacy sections were written for a busy health-care professional, and should enable one to ascertain which clinical uses are supported by clinical data, without having to read through all the pharmacology. Each chapter is fully referenced, enabling the reader to access further information when necessary.
Designed as a guide for the coating formulator and technologist as well as a reference for students, this handbook offers practical information, data, and references needed to understand and solve coating problems.
Written in a quick-review format perfect for the busy student and clinician, this Second Edition stands as the most illustrative and in-depth guide available to prepare for the gastroenterology board and recertification exams. Supplying readers with an armamentarium of case-based presentations, 219 quality images, and more than 400 references for f
The battle for the United Planets hits a fever pitch as the galactic conqueror Mongul beats some of the rulers of the galaxy to death and then heads for Earth! The only thing standing in his way? Superman! Meanwhile, back on Earth, the truth that Clark Kent is Superman continues to spiral out all over the world, and now the Daily Planet’s competition is gunning for his wife, Lois Lane!
This book examines the Japanese government policies that impact on the environment in order to determine whether they incorporate a sufficient ethical substance. Through the three case studies on whaling, nuclear energy, and forestry, the author explores how Western philosophers combined their theories to develop a ‘Western environmental ethics code’ and reveals the existence of a unique ‘Japanese environmental ethics code’ built on Japan’s cultural traditions, religious practices, and empirical experiences. Kagawa-Fox’s discussions show that in spite of the positive contributions that Japan has made towards the global environment, the government has failed to show a correspondin...