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Mouse Phenotypes
"The laboratory mouse is an important model in biomedical research. This volume provides the concepts and tools needed to generate mutant mice and analyze their phenotypes"--
Mouse Phenotypes
The generation of mutant mice raises many questions about the best means of phenotypic analysis, breeding, and maintenance. The answers are now available from two experts with a wealth of detailed knowledge never previously assembled in one volume. Informal and highly practical, this handbook provides step–by–step methods for troubleshooting experiments, from the basics of gene targeting through the analysis of postnatal effects.
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Mouse Phenotypes
"The laboratory mouse is an important model in biomedical research. This volume provides the concepts and tools needed to generate mutant mice and analyze their phenotypes"--
Experimental Approaches to Mammalian Embryonic Development
Recent advances in the experimental analysis of the mammalian embryo are discussed from various scientific perspectives in this summary of major breakthroughs in embryonic development.
The Ethics of Embryonic Stem Cell Research
Embryonic stem cell research holds unique promise for developing therapies for currently incurable diseases and conditions, and for important biomedical research. However, the process through which embryonic stem cells are obtained involves the destruction of early human embryos. Katrien Devolder focuses on the tension between the popular view that an embryo should never be deliberately harmed or destroyed, and the view that embryonic stem cell research, because of its enormous promise, must go forward. She provides an in-depth ethical analysis of the major philosophical and political attempts to resolve this tension. One such attempt involves the development of a middle ground position, whi...
International Review of Cytology
International Review of Cytology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Point Particles to Capture Polarized Embryonic Cells & Cold Pools in the Atmosphere
Part 1: How are the incredible diversity and robustness compatible with animal morphologies? Based on apical-basal and planar cell polarities’ ubiquity, I suggest a 3D mathematical model: Point particles represent cells having zero, one, or two unit-arrows representing polarities. I test the model abilities on preimplantation development, sea urchin gastrulation, mammalian neurulation, organoid folding, and tubulogenesis. I find that a minimal, versatile toolbox, including cellular polarities, captures the emergence of diverse and robust animal morphologies. Part 2: How are deep convective events spatially organized in the tropical atmosphere? Here, I test the importance of atmospheric cold pools for organizing convection. I suggest a 2D mathematical model: Points expand into circles representing cold pools. When circles meet, a convective event occurs, and a new circle forms. I find this model captures convective scale increase and initial stages of convective self-aggregation. The latter is crucial due to its link to tropical cyclogenesis.
The Harvey Lectures
This latest volume in the Harvey Lectures Series reflects "the evolution of physiology and physiological chemistry into biochemistry and the development of molecular biology from the roots of bacteriology and biochemistry" in the 20th and 21st centuries. This lecture series, collected and published annually, provides a series of distinguished lectures in the life sciences by world-renowned scientists in all areas of biomedicine. These lectures occur in New York City throughout the course of each academic year.
