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Preleukemia
Clinical hematologists are frequently faced with the intriguing problem of agnogenic myelo dysplastic syndromes; these syndromes are peculiar in their failing or poor response to therapy and in that they frequently terminate in acute leukemia. An international symposium held in Innsbruck in 1978 was dedicated to clinical and pathophysiologic aspects of the preleukemic syndromes. This monograph consists of articles that correspond to the papers presented at the symposium and of the edited discussions. It was the aim of the symposium and of this monograph to outline comprehensively the pathophysiologic background of the preleukemic syndromes and to summarize the present information about their...
The Northern North Atlantic
The northern North Atlantic is one of the regions most sensitive to past and present global changes. This book integrates the results of an interdisciplinary project studying the properties of the Greenland-Iceland-Norwegian Seas and the processes of pelagic and benthic particle formation, particle transport, and deposition in the deep-sea sediments. Ice-related and biogeochemical processes have been investigated to decipher the spatial and temporal variability of the production and fate of organic carbon in this region. Isotopic stratigraphy, microfossil assemblages and paleotemperatures are combined to reconstruct paleoceanographic conditions and to model past climatic changes in the Late Quaternary. The Greenland-Iceland-Norwegian Seas can now be considered one of the best studied subbasins of the world`s oceans.
Cytotoxic Payloads for Antibody–Drug Conjugates
Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (Kadcyla™), brentuximab vedotin (Adcetris™), inotuzumab ozogamicin (Besponsa™), gemtuzumab ozogamicin (Mylotarg™) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages in...
Annual Review of Materials Science
Provides abstracts and full text to articles on materials science.
The Chemistry of Antitumour Agents
Walter C. J. ROSS Emeritus Professor, University of London To paraphrase a statement made by Howard E. Skipper many years ago, 'We cancer chemotherapists have often exploited and overworked our chemist colleagues and they have been conveniently forgotten at award giving times'. This book is an attempt to rectify this and highlight the contribution of the chemist in modifying the structure of various types of agent to enhance their effectiveness as inhibitors of the growth of neoplastic tissues. Cancer chemotherapy is a relatively new discipline, coming later than the introduction of sulphonamides and antibiotics. Modern anti-cancer therapy started with the report of the use of a war gas meth...
Renewable Energy Based Solutions
This book discusses the main renewable energy resources, along with the current challenges that make it difficult achieve 100% decarbonized energy sources. It presents the perspectives of international expert authors in the field, giving readers a multi-dimensional view of the subject. The book explores numerous approaches for a smooth transition from fossil fuels to renewable energies, including those based on engineering methods, as well as policies, strategies, and social perceptions. It presents several case studies and examples from industry, showcasing the potential role of renewable sources and their challenges. The inclusion of both established methods and cutting-edge developments will make this book of interest to academics, industry professionals, policy makers, and graduate students alike.
Nanostructured Materials for Energy Related Applications
This book describes the role and fundamental aspects of the diverse ranges of nanostructured materials for energy applications in a comprehensive manner. Advanced nanomaterial is an important and interdisciplinary field which includes science and technology. This work thus gives the reader an in depth analysis focussed on particular nanomaterials and systems applicable for technologies such as clean fuel, hydrogen generation, absorption and storage, supercapacitors, battery applications and more. Furthermore, it not only aims to exploit certain nanomaterials for technology transfer, but also exploits a wide knowledge on avenues such as biomass-derived nanomaterials, carbon dioxide conversions into renewable fuel chemicals using nanomaterials. These are the areas with lacunae that demand more research and application.
Flexible Electronics
This excellent volume covers a range of materials used for flexible electronics, including semiconductors, dielectrics, and metals. The functional integration of these different materials is treated as well. Fundamental issues for both organic and inorganic materials systems are included. A corresponding overview of technological applications, based on each materials system, is presented to give both the non-specialist and the researcher in the field relevant information on the status of the flexible electronics area.
