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A thought-provoking book on the archaeology of power, knowledge, social memory, and the emergence of classical tradition in early China.
This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Frontiers of Civil Engineering and Disaster Prevention and Control is a compilation of selected papers from The 3rd International Conference on Civil, Architecture and Disaster Prevention and Control (CADPC 2022) and focuses on the research of architecture and disaster prevention in civil engineering. The proceedings features the most cutting-edge research directions and achievements related to construction technology and prevention and control of disaster. Subjects in this proceedings include: Construction Technology Seismicity in Civil Engineering High-Rise Building Construction Disaster Preparedness and Risk Reduction Smart Post-Disaster Rescue These proceedings will promote development of civil engineering and risk reduction, resource sharing, flexibility and high efficiency. Moreover, promote scientific information interchange between scholars from the top universities, research centers and high-tech enterprises working all around the world.
Autophagy (“auto-digestion”), a lysosome-dependent process, degrades and turns over damaged or senescent organelles and proteins. Autophagy is a highly regulated process that impacts several vital cellular responses, including inflammation, cell death, energy metabolism, and homeostasis of organelles (mitochondria and others). Although the role of autophagy in the maintenance of tissue homeostasis is well documented, its role during tissue injury and regeneration is still emerging. In this Special Issue on “Autophagy in Tissue Injury and Homeostasis”, we focus on the roles of autophagy in systemic, specific tissue (organs/cells) injury or organ failure associated with sepsis, inflammation, metabolic disorder, toxic chemicals, ischemia-reperfusion injury, hypoxic oxidative stress, tissue fibrosis, trauma, and nutrient starvation. The knowledge gained from the identification and characterization of new molecular mechanisms will shed light on biomedical applications for tissue protection through the modulation of autophagy.
This book constitutes selected papers presented during the Third China Annual Intelligent Robotics Conference, CCF CIRAC 2022, held in Xi' an, China, in December 2022. The 35 papers presented were thoroughly reviewed and selected from the 120 qualified submissions. They are organized in the following topical sections: robot safety; intelligent robot sensing; autonomous robot navigation; artificial intelligence and cloud robot; unmanned cluster collaboration; natural human-computer interaction; other robot-related technologies.
This book highlights the characteristics, aims, and applications of microorganisms as a crucial solution for sustainable management of the toxic pollutants in aquatic ecosystems, soil, and air. It facilitates biotechnology towards the development of more sustainable biological systems by minimizing the level of harmful toxic substances and reducing the toxic effects in current chemical processes. It serves as a useful guide for a diverse community of practicing professionals, researchers, students (undergraduate and postgraduate), innovators involved in biotechnology research, and policymakers engaged in the development of strategies to deal with challenges of current environmental issues an...