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Emerging Molecular Signaling Pathways and Therapeutic Targets in the Genitourinary Immune Microenvironment
It is well known that the immune microenvironment is critical to the progression of genitourinary malignancies and benign diseases. A variety of cellular and molecular properties of the immune microenvironment may influence disease outcome by altering the balance of suppressive versus inflammatory or cytotoxic responses. Emerging evidence suggests that immunoediting is a key factor of phenotypic change, immunological alterations caused by physical activity or drug treatments could promote antitumor or anti-inflammatory activity. Conversely, microenvironment deficits or dysregulation can instigate or worsen pathological progression, thereby contributing to urinary disease development and prog...
Advanced Materials for Batteries
The rise of renewable energy responds to global warming, necessitating reliable storage like batteries. Though frequent use can affect their lifespan, these have become smaller, simpler, and more adaptable. Recent technological progress has improved batteries' longevity and efficiency, with costs dropping due to mass production. This book examines different battery types, their evolution, and the cutting-edge materials enhancing their performance, particularly focusing on metal oxides in various battery technologies. Exploring advanced materials for batteries is not just a theoretical exercise but a practical journey into the future of energy. This book is an essential guide, tracing the evo...
Modeling and State Estimation of Automotive Lithium-Ion Batteries
This book aims to evaluate and improve the state of charge (SOC) and state of health (SOH) of automotive lithium-ion batteries. The authors first introduce the basic working principle and dynamic test characteristics of lithium-ion batteries. They present the dynamic transfer model, compare it with the traditional second-order reserve capacity (RC) model, and demonstrate the advantages of the proposed new model. In addition, they propose the chaotic firefly optimization algorithm and demonstrate its effectiveness in improving the accuracy of SOC and SOH estimation through theoretical and experimental analysis. The book will benefit researchers and engineers in the new energy industry and provide students of science and engineering with some innovative aspects of battery modeling.
Exploring the Human Plasma Proteome
On the cutting edge of medical diagnostics, plasma proteomics promises to generate a new wave of technologies to help identify many different diseases and disease risks. Plasma and serum are the preferred non-invasive specimens to test normal individuals, at-risk groups, and patients for protein biomarkers discovered and validated to reflect physiological, pathological, and pharmacological phenotypes. These specimens present enormous challenges due to extreme complexity, huge dynamic range in protein concentrations, non-standardized methods of sample processing, and intra- and inter-individual variation from genetics, diet, smoking, hormones, and other sources. This book presents the major findings from the collaborative Plasma Proteome Project organized by the international Human Proteome Organization (HUPO). The chapters are drawn from a larger set of publications in the journal PROTEOMICS. This book provides a valuable foundation for development and applications of proteomics.
Genomic Discoveries and Pharmaceutical Development in Urologic Tumors
Urologic tumors encompass cancers of the prostate, bladder, kidney, testis, and adrenal glands. Recent years have witnessed significant advancements in understanding the genomic landscape of urologic tumors, leading to the emergence of novel therapeutic strategies. A particularly exciting area of research lies in genomic sequencing, enabling the identification of specific genetic mutations and biomarkers that can be targeted with drugs. For instance, drugs targeting the androgen receptor (AR) pathway, such as abiraterone and enzalutamide, have shown efficacy in treating prostate cancers with genetic alterations in this pathway. Additionally, drugs like sunitinib and pazopanib, which target the vascular endothelial growth factor (VEGF) pathway, have significantly improved survival rates for patients with metastatic renal cell carcinoma (RCC).
Advances in Heat Transfer and Thermal Engineering
This book gathers selected papers from the 16th UK Heat Transfer Conference (UKHTC2019), which is organised every two years under the aegis of the UK National Heat Transfer Committee. It is the premier forum in the UK for the local and international heat transfer community to meet, disseminate ongoing work, and discuss the latest advances in the heat transfer field. Given the range of topics discussed, these proceedings offer a valuable asset for engineering researchers and postgraduate students alike.
Fuel Cell Hybrid EVs
With production and planning for new electric vehicles gaining momentum worldwide, this book – the fifth in a series of five volumes on this subject – provides engineers and researchers with perspectives on the most current and innovative developments regarding electric and hybrid-electric vehicle technology, design considerations, and components. This book features 14 SAE technical papers, published from 2008 through 2010, that look at innovative engineering approaches to meeting the major technological challenges associated with fuel cells. Topics covered include: Advances in powertrain systems for fuel cell vehicles Diagnostic design processes for developmental vehicles Application of two fuel cells in hybrid electric vehicles Research and design of a centrifugal compressor for fuel cell turbocharger The future of fuel cell hybrid EVs
Vibration of Hydraulic Machinery
Vibration of Hydraulic Machinery deals with the vibration problem which has significant influence on the safety and reliable operation of hydraulic machinery. It provides new achievements and the latest developments in these areas, even in the basic areas of this subject. The present book covers the fundamentals of mechanical vibration and rotordynamics as well as their main numerical models and analysis methods for the vibration prediction. The mechanical and hydraulic excitations to the vibration are analyzed, and the pressure fluctuations induced by the unsteady turbulent flow is predicted in order to obtain the unsteady loads. This book also discusses the loads, constraint conditions and the elastic and damping characters of the mechanical system, the structure dynamic analysis, the rotor dynamic analysis and the system instability of hydraulic machines, including the illustration of monitoring system for the instability and the vibration in hydraulic units. All the problems are necessary for vibration prediction of hydraulic machinery.
Mining Science and Technology 1996
A collection of symposium papers covering all major aspects of mining and related disciplines. Topics include: mining science; environmental and safety technology; mine control; antomation and mechanization; mining geomechanics; mine construction and engineering; and coal processing.
Proceedings of the 10th Chinese Society of Aeronautics and Astronautics Youth Forum
The Chinese Society of Aeronautics and Astronautics holds the Youth Science and Technology Forum biannually, which aims to assess the state of aviation science and technology, recognize advanced scientific and technological accomplishments, foster the development of young aviation science and technology talents, and provide a platform for young science and technology workers to track the frontier of science and technology, exchange novel ideas, and accurately meet the needs of the aviation industry. This book contains original, peer-reviewed research papers from the conference. Topics covered include, but are not limited to, navigation, guidance and control technologies, key technologies for...
