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This book demonstrates the potential of urine as a biomarker resource for early disease detection, covering the related theory, strategies, tools and findings. Biomarkers are measurable changes associated with diseases. Blood, as a critical part of its internal environment, is closely monitored and controlled by the body to maintain homeostasis, especially in the early stages of diseases. In contrast, urine, as a form of waste excreted by the body, collects a variety of substance changes. Accordingly, urine can offer an ideal resource for early biomarker discovery. In addition, urine is more stable than blood in vitro, and is easy to store and analyze. The book discusses exciting preliminary applications of urine biomarkers for diseases affecting major biological systems. Its main goal is to make scientists, clinicians and medical companies aware of this important, exciting, undeveloped, and profitable field.
Translational Urinomics provides an overview of urine analysis using proteomics, metabolomics, transcriptomics or any combination thereof for the diagnosis and prognosis of diseases related to the urinary system and the kidneys. The text approaches urine biomarkers from a new perspective, incorporating up-to-date studies of mass-spectrometry-based biomarker discovery as well as the latest advances in personalized medicine. The integration of technology-driven techniques, such as OMICS also provides a unique opportunity for improved diagnostics accuracy of urinary-related diseases. For nephrologists and urologists looking for new approaches to well-known problems, this edited volume serves as a valuable guide.
This book systematically summarizes the ideas and technologies used in urine proteome analysis. It argues that change is the core of biomarker definition since the body uses its homeostatic mechanisms to correct changes in the blood. This means that urine is probably a better source of biomarkers than blood. A roadmap to the urinary biomarker era is proposed, and researchers are reminded of the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce the most significant changes in urine. This book tries to show researchers and graduate students, who are in or entering the field, "all things considered" rather than "the current affair".
Based on research and results from the international Human Kidney and Urine Proteome Project, this handbook and reference presents current methods and protocols for the analysis of human kidney and urine. The world's leading experts cover everything from basic techniques for routine analysis to advanced methods for difficult samples or analytes. Written with the practitioner in mind, all the methods and techniques are described with step-by-step protocols backed by much valuable practical advice taken from real life experiments.
This book introduces the concept of reciprocal educational learning among cultures with very different historical and philosophical origins. The concept of reciprocal learning grows out of a four year study of immigrant Chinese family narrative experiences in a Western context. This book captures the lived moments of such transitional lives both in and out of school settings to demonstrate why a child would appear and disappear from different caregivers’ purview. Through the narrative lens of student and family life, the study illustrates the intersection of Confucian and Western philosophies of education and how their interaction creates complications as well as benefits for both traditions, hence, the idea of reciprocal learning.
Narrative inquiry is being used more widely in the UK, the USA, Canada, Australia, New Zealand and Northern European countries to conduct research across a range of disciplines. It is gaining popularity in Hong Kong, Macao and Mainland China, but research in these contexts continues to be dominated by quantitative and more traditional qualitative approaches. Narrative inquirers in these areas can, therefore, find it problematic to have the value of their work acknowledged. This book demonstrates creatively, accessibly and rigorously the ways in which narrative inquiry as a methodological approach, already more firmly established in Australia and New Zealand, is gaining a foothold in other pa...
This PALART volume makes an original addition to the Series as it opens a stimulating window on the Asia-Pacific region of the world by bringing together a great deal of empirical and theoretical new work in Second Language Acquisition within the Processability Theory (PT) framework. Readers will be pleasantly surprised to be able to access, within one publication, so much novel and overview information on SLA while maintaining its focus on PT, its theoretical developments including its 2005 (Pienemann et al.) and 2015 (Bettoni & Di Biase) extensions and how they relate to PT’s foundation work (Pienemann 1998), as well as its applications to language learning and teaching in Japanese, Chinese, Hindi, Malay and English in countries of the Asia-Pacific region including Australia. This volume demonstrates the vitality and the dynamic nature of PT and its potential as a tool for understanding SLA both theory and practice.
Fortunes of Officials is a story about the whole process of StrongIdeal Gao to become the most powerful person-- the secretary from deputy secretary of municipal committee of Near Violet City with a population of seven million people and to resign from the post. Like other place, Near Violet was filled opportunities, restlessness and uneasiness in the transformation period. As the most powerful person in the city, StrongIdeal Gao had to face various enticements and schemes and sufferings, but he withstood various challenges, took the great opportunities of the Reform and Opening Door Policy, and made a great contribution to the economic development of the city under the tenet: As the most powerful person in the place, local people must benefit from his performance, thus he was well loved by the people of the city. The novel described the officials working at the city level using a documentary method about their political fortunes and personal trails from a positive angle with the ups and downs and lively scenes. The novel was a signature novel which laid foundation for the author to become the well-known author about officialdom in China.