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Protein Interactions as Targets in Drug Discovery
Protein Interactions as Targets in Drug Discovery, Volume 121, is dedicated to the design of therapeutics, both experimental and computational, that target protein interactions. Chapters in this new release include Trends in structure based drug design with protein targets, From fragment- to peptide-protein interaction: addressing the structural basis of binding using Supervised Molecular Dynamics (SuMD), Protein-protein and protein-ligand interactions: identification of potential inhibitors through computational analysis, Aromatic-aromatic interactions in protein-drug and protein-protein interactions, Role of protein-protein interaction in allosteric drug design within the human methyltransferome, and much more.
Biomedical Translational Research
This book, which is the first volume of Biomedical Translational Research, summarizes emerging technologies in healthcare. The book reviews the advancements in biomedical sciences in genomics, immunology, stem cell, tissue engineering, nanotechnology, computational and structural biology, biomedical engineering, and telemedicine biology. The book highlights the applications of artificial intelligence in the diagnosis of infectious diseases and examines the role of system biology approaches for understanding human complexity, variability, and its influence on health and diseases. It presents the applications of flow cytometry in monitoring the progression and treatment of disease. It covers emerging technologies in cancer research, including CRISPR-Cas9, NGS, and nanotechnology. This book is a useful source of information for clinical researchers, basic scientists, biomedical engineers, and computational biologists.
The Impact of Climate Change on Vulnerable Populations
Climate change and urban development threaten health, undermine coping and deepen existing social and environmental inequities. A changing global environment requires transformative social responses: new partnerships, deep engagement with local communities, and innovation to strengthen individual and collective assets. The chapters of this edited volume have mainly been contributed by established and emerging scholars representing social work, sociology, development studies, law, government, social anthropology, urbanism, public policy, and other social sciences This book is to be used for academics, policy makers, social work students, lecturers and other stakeholders to promote advocacy for vulnerable client groups affected by climate change. It gives some measure of hope and makes the invisible visible, allowing for change.
Evolution of Genetic Mechanisms of Antibiotic Resistance
Since the first introduction of antibiotics into clinical practice, microbial drug resistance has emerged as a major obstacle in the treatment of infections. Recently, the combination of emergence of a complex variety of multidrug resistant strains and the dearth of newly discovered molecules to effectively target and eliminate these strains, has made antibiotic resistance one of the major public health problems of this century. Although different strategies can be adopted to contain the emergence and spread of antibiotic resistance, including (i) antimicrobial stewardship, (ii) infection control, and (iii) tighter control over the use of antibiotics in agriculture and breeding, a better und...
Eco-Restoration of Polluted Environment
The book Eco-Restoration of the Polluted Environment: A Biological Perspective explores recent advances in biological strategies for the remediation of polluted environments, including soil, water, and air. It covers bioremediation of heavy metals, radioactive waste, and waste gases, which are believed to be bottleneck problems for researchers working in this field. The book contains separate chapters on genetic engineering technology for enhancement of the bioremediation potential of bioresources and the role of biosurfactants, enzymes, and exo-polysaccharides for bioremediation of polluted environments, along with basic aspects of eco-restoration by microorganisms. It summarizes the signif...
Emerging Contaminants in Food and Food Products
In recent years, a wide variety of new chemicals have continued to be developed as a result of industrial development and associated anthropogenic activities. The microbial contaminants in the environment, more precisely, antibiotic-resistant genes/bacteria produced as a result of mutation due to antibacterial drugs, are also considered emerging contaminants and specifically called emerging microbial contaminants such as sapoviruses, Waddlia chondrophila and Streptococcus parauberis. Additionally, pharmaceuticals and personal care products are a diverse group of compounds that include ibuprofen, diclofenac, triclosan, antibiotics, anti-inflammatory agents, steroidal hormones and active ingre...
Applications of STEM (Science, Technology, Engineering and Mathematics) Tools in Microbiology of Infectious Diseases
Epidemiology is a discipline intended to systematically investigate, and ideally quantify, disease dynamics in populations (Perez, 2015). Epidemiological assessmentsmay be divided into four large areas, namely, (a) identification and characterization of a pathogen, (b) development of systems for detection of cases, (c) descriptive epidemiology and quantification of disease patterns, and (d) advanced analytical methods to design intervention strategies. Briefly, there is an initial need for understanding the pathogeny of a disease and condition, which may also include experimental studies and development of new models of infection and proliferation under different conditions. Subsequently, su...
Algae and Fungi
This book discusses algae and fungi as the tools for decontamination of polluted environments and how the remediation techniques aid in biorefining the pollution in environmentally sustainable ways. It covers their applications in containing and controlling pollution along with detailed diagrammatic representations including mechanisms of phyco- and myco-remediation. Recovery of pollutants including heavy metals, pesticides, organic chemicals, radionuclides, and persistent chemicals from polluted ecosystems and wastewater is also covered. Exclusively covers phyco- and myco-remediation of various pollutants Reviews dynamics of pollution abatement related to algae as well as fungi Covers recovery of the pollutants from polluted ecosystems Advocates usage of multiple modes of fungi and algae for detoxification of different compounds Discusses restoration of the degraded ecosystems This book is aimed at researchers and graduate students in environmental engineering, algae and fungi biotechnology, applied microbiology, and phycology.
