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Change and Continuity in North Korean Politics
In the years since the death of Kim Jong-il and the formal acknowledgement of Kim Jong-un as head of state, the North Korean regime has made a series of moves to further augment and consolidate the ideological foundations of Kimism and cement the young leader’s legitimacy. Historical narratives have played a critical, if often unnoticed, role in this process. This book seeks to chronicle these historical changes and continuities. Continuity and Change in North Korean Politics explores the stable and shifting political, cultural and economic landscapes of North Korea in the era of Kim Jong-un. The contributors deploy a variety of methodologies of analysis focused on the content, narratives ...
Organic Chemistry Editor's Pick 2024
We are pleased to introduce the collection Frontiers in Chemistry – Organic Chemistry Editor’s Pick 2024. This collection showcases the most well-received spontaneous articles from the past couple of years, and have been specially handpicked by our Chief Editor. The work presented here highlights the broad diversity of research performed across the section, and aims to put a spotlight on the main areas of interest. All research presented here displays strong advances in theory, experiment and methodology with applications to compelling problems. This collection aims to further support Frontiers’ strong community by recognizing highly deserving authors.
ZB 2005: Formal Specification and Development in Z and B
This book constitutes the refereed proceedings of the 4th International Conference of Z and B users, ZB 2005, held in Guildford, UK in April 2005. The 25 revised full papers presented together with extended abstracts of 2 invited papers were carefully reviewed and selected for inclusion in the book. The papers document the recent advances for the Z formal specification notation and for the B method, ranging from foundational, theoretical, and methodological issues to advanced applications, tools, and case studies.
The Chinese Filmography
From A to Z, Abandon Superstitions (1958; Po Chu Mi Xing in Chinese) to Zuo Wenjun and Sima Xiangru (1984; Zuo Wen Jun Ahe Si Ma Xiang Ru), this comprehensive reference work provides filmographic data on 2,444 Chinese features released since the formation of the People's Republic of China. The films reflect the shifting dynamics of the Chinese film industry, from sweeping epics to unabashedly political docudramas, although straight documentaries are excluded from the current work. The entries include the title in English, the Chinese title (in Pinyin romanization with each syllable noted separately for clarity), year of release, studio, technical information (e.g., black and white or color, letterboxed or widescreen), length, technical credits, literary source (when applicable), cast, plot summary, and awards won.
Abstraction, Refinement and Proof for Probabilistic Systems
Illustrates by example the typical steps necessary in computer science to build a mathematical model of any programming paradigm . Presents results of a large and integrated body of research in the area of 'quantitative' program logics.
Discovery and Total Synthesis of Bio-functional Natural Products from Traditional Medicinal Plants
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Precision Medicine in Gastrointestinal Cancers
Precision medicine is the main emphasis in healthcare after recognizing the importance to integrate the clinical data with the molecular data of a specific disease. The term was first introduced in 2015 in which the Precision Medicine Initiative was initiated with the final aim to provide targeted therapy with high efficacy and less toxicity. Precision medicine plays an increasingly important in gastrointestinal cancers. Gastrointestinal cancers are divided into the upper (esophagus, stomach) and lower part (hepatobiliary and colon) of the gastrointestinal system. We would like to explore the latest era of integrative therapeutic target in gastrointestinal cancers taking into consideration of various aetiologies including genetic and exposome (dietary factors, microbial, hormonal, environmental insults) and their interactions with the host microenvironment.
Reagents for Silicon-Mediated Organic Synthesis
Over the last three decades the importance of organosiliconchemistry has greatly increased because it has opened a number ofnew synthetic strategies. Silicon reagents are usually low-cost,versatile and allow a wide range of reactions. This is the firstHandbook to compile essential Silicon containing reagents and makesuse of the leading reagent database e-EROS. Another hotvolume in the series Handbooks of Reagents for OrganicSynthesis, this is a must-have resource for all syntheticchemists working in drug development and medicinal chemistry. For the selection the Editor focussed on three key syntheticapproaches with the greatest impact: 1. Use of silicon as a 'temporary tether' by unifying a ...
Immune Responses Against Tumors - From the Bench to the Bedside
Traditionally, surgery, radiotherapy, chemotherapy and hormonal therapy have been used in clinical practice to treat cancer patients. However, these methods are either not completely tumor free or without collateral damage to health tissues. Therefore, tumor recurrence, partial remission, treatment side effect and poor tolerance in elderly patients, and lack of effective strategy to treat late-stage cancers have been the major hurdles faced by clinicians in health care. Although cancer immunotherapy including checkpoint blockade, CAR-T, oncolytic viruses, and recombinant cytokines has taken center stage in mainstream oncology because of its specifically targeting tumor cells without affecting surrounding normal cells, only a proportion of patients receiving treatment respond and others relapse after an initial response. Different tumor indications respond differently, and even in cancer types that respond, unresponsiveness are still observed. This resistance suggests that either lack of sufficient host recognition and immunity (intrinsic) or active immune suppression by tumor complex (acquired).
