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Pain Research Progress
Pain is an unpleasant sensation. It is defined by the International Association for the Study of Pain (IASP) as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage". Pain is part of the body's defence system: it triggers mental problem-solving strategies that seek to end the painful experience, and it promotes learning, making repetition of the painful situation less likely. The nociceptive system transmits signals that usually trigger the sensation of pain, it is a critical component of the body's ability to react to damaging stimuli and it is part of a rapid-warning relay instructing the central nervous system to initiate reactions for minimising injury. This book presents the latest research in the field from around the globe.
Engineering of Microbial Biosynthetic Pathways
This book provides a comprehensive overview of the basic and advanced metabolic engineering technologies used to generate natural metabolites and industrially important biomolecules. Metabolic engineering has the potential to produce large quantities of valuable biomolecules in a renewable and sustainable manner by extending or modifying biosynthetic pathways in a wide range of organisms. It has been successfully used to produce chemicals, drugs, enzymes, amino acids, antibiotics, biofuels, and industrially important pharmaceuticals. The book comprehensively reviews the various metabolites detection, extraction and biosensors and the metabolic engineering of microbial strains for the product...
Advances in the Synthesis and Catalytic Applications of Boron Cluster
Advances in Catalysis, Volume 71 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Advances in the catalytic and photocatalytic behavior of carborane derived metal complexes, Transition metal catalyzed synthesis of derivatives of polyhedral boron hydrides with B-N, B-P, B-O and B-S bonds, Recent advances in transition metal catalyzed selective cage BH functionalization of o-carboranes, Boron Compounds for Catalytic Applications, Regioselective Carborane B-H/C-H Functionalization, and Derivatization of monocarborane and dodecaborate anions by controlled B–H activation. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Advances in Catalysis serials - Updated release includes the latest information on advances in the synthesis and catalytic applications of boron cluster
Brain Hypoxia and Ischemia
Brain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia. Chapters focus on a panorama of issues including the role of ion channels/transporters, mitochondria and apoptotic mechanisms, the roles of glutamate/NMDA, mechanisms in penumbral cells and the importance of intermittent hypoxia and gene regulation under these stressful conditions. The volume explores findings from both mammalian and invertebrate model systems and their applicability to human systems and diseases. Careful consideration is also given to differences in hypoxia and ischemia across development. This volume aims to increase the understanding of these mechanisms and to stimulate research on better diagnosis and treatment of diseases that afflict the brain and potentially other organs when O2 levels are dysregulated. Brain Hypoxia and Ischemia is designed for neuroscientists, clinicians and medical/graduate students for use in both basic research and clinical practice.
Single Molecular Machines and Motors
Single Molecular Machines and Motors brings together different approaches and strategies to design, synthesize and study single molecular machines and motors in a multidisciplinary way. Written by leading international experts, this book summarizes the advances in the field through a number of disciplines. Some contributions describe molecular chemistry such as organic, aromatics, and coordination chemistry while others address theoretical chemistry in a predictive way or through post-experimental modelling. Experimental physics with extensive use of scanning probe microscopy (STM and AFM) is discussed for examining one single molecule. This book is aimed at those who are interested in the rapidly growing field of molecular machines and motors acting and studied at the single-molecule scale. The goal of the authors and editors is to provide the reader with an up-to-date summary while also offering future perspectives on the field.
Systems Biology of MicroRNAs in Cancer
This book provides an update on the latest development in the field of microRNAs in cancer research with an emphasis on translational research. Since the early 2000s, microRNAs have been recognized as important and ubiquitous regulators of gene expression. Soon it became evident that their deregulation can cause human diseases including cancer. This book focuses on the emerging opportunities for the application of microRNA research in clinical practice. In this context, computer models are presented that can help to identify novel biomarkers, e.g. in circulating microRNAs, and tools that can help to design microRNA-based therapeutic interventions. Other chapters evaluate the role of microRNAs in immunotherapy, immune responses and drug resistance. Covering key topics on microRNAs in cancer research this book is a valuable resource for both emerging and established microRNA researchers who want to explore the potential of microRNAs as therapeutic targets or co-adjuvants in cancer therapies.
Gels Handbook: Fundamentals, Properties, Applications (In 3 Volumes)
Hydrogels are made from a three-dimensional network of cross linked hydrophilic polymers or colloidal particles that contain a large fraction of water. In recent years, hydrogels have attracted significant attention for a variety of applications in biology and medicine. This has resulted in significant advances in the design and engineering of hydrogels to meet the needs of these applications. This handbook explores significant development of hydrogels from characterization and applications. Volume 1 covers state-of-art knowledge and techniques of fundamental aspects of hydrogel physics and chemistry with an eye on bioengineering applications. Volume 2 explores the use of hydrogels in the interdisciplinary field of tissue engineering. Lastly volume 3 focuses on two important aspects of hydrogels, that is, drug delivery and biosensing. Contains 50 colour pages.
Sustainable Crop Disease Management using Natural Products
Alternative methods of disease control such as natural products and compounds derived from biological origins, provide an effective alternate to the use of chemical products or a means to minimize their use. It is imperative now to look for such sustainable crop disease management approaches, that include routine and alternative methods. Natural products for sustainable crop disease management is an effort in this direction, and deals with immediate concerns in the field of natural and alternative products for disease control, apart from using biocontrol organisms. This book presents up-to-date information on natural products and compounds derived from biological origins and thoroughly discusses their applicability, field use and prospects for adoption under different cropping conditions. This book also validates disease management strategies.
Mitochondrial Signaling in Health and Disease
Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic
