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Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
The considerable number of viral infectious disease threats that have emerged since the beginning of the 21st century have shown the need to dispose global and coordinated responses to fight properly and efficiently against them. Severe acute respiratory syndrome (2003), avian influenza in humans (2005), A(H1N1) pandemic influenza (2009), Middle East respiratory syndrome coronavirus (MERS-CoV) (2012 onward) and Ebola virus disease (2014-2015) are some of the most important examples. The latest emerging and devastating threat was Zika virus, an arbovirus that provoked more than 500,000 suspicious cases in the Americas in 2016 and notable processes of social and medical alarms due to the evide...
Highly Mutable Animal RNA Viruses: Adaptation and Evolution
Viruses are widely present in nature, and numerous viral species with a variety of unique characteristics have been identified so far. Even now, new emerging or re-emerging viruses are being found or re-found as novel viral classes or as quasi-species. Indeed, viruses are everywhere. Of note, viruses are pivotal as targets and tools of basic and applied sciences. On one hand, portions of the viruses are infectious for animals including humans, and cause various diseases in infected hosts by distinct mechanisms and at a different level of severity. While many of viruses are known to co-exist quietly with their hosts, pathogenic viruses certainly affect and threaten our society as well as indi...
Lipid Metabolism
Lipids (fats and oils) are a wide range of organic molecules that serve several functions in organisms. Lipids are essential components of our diet, highlighting their important contribution in energy, representing 9 kcal/g (or 37.7 kJ/g), and by some components relevant to the metabolism, such as essential fatty acids, fat soluble vitamins and sterols (cholesterol and phytosterols). Besides this, lipids have key roles in human growth and development, along with promoting, preventing and/or participating in the origin or eventually in the treatment of various diseases. This book presents a systematic and comprehensive review about the structure and metabolism of lipids, particularly highlighting the importance of these molecules in the body and considering the interest of some lipids in health and disease.
The Charnoly Body
Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alope...
Host-Pathogen Interactions During Arboviral Infections
Arboviruses, or arthropod-borne viruses, such as West Nile virus, Dengue virus, and Zika virus, pose a serious threat to public health worldwide. West Nile virus was introduced to the United States in 1999, and is now endemic, causing over 2,000 domestically acquired cases in the U.S. annually in mammals. Similarly, dengue and Zika viruses are endemic in the Americas and pose novel threats to the human population. Tick-borne viruses such as Powassan virus and Heartland virus are increasing in frequency in the U.S. At this time, there is no commercially available vaccine or therapeutic to treat these viral infections. Because nearly every mammalian case of these virus infections originates fr...
Antiviral Strategies
A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development.
Fuerteventura
On the island of Fuerteventura, the Germans have built a house of 'rest' that offers all kinds of pleasure to their submarine officers after hard months in the deep sea. The British secret service to infiltrate Erika Simon, German Jewish exile in England, in the group of prostitutes who enliven the leisure hours of the Germans. Its mission is to gather as much information as possible about the movement of the dreaded submarines. Your risk, involve your heart in an unexpected relationship. His dilemma, trapped in a terrifying crossroads: betray your allies or betray her lover ...
The Case for Marriage
A groundbreaking look at marriage, one of the most basic and universal of all human institutions, which reveals the emotional, physical, economic, and sexual benefits that marriage brings to individuals and society as a whole. The Case for Marriage is a critically important intervention in the national debate about the future of family. Based on the authoritative research of family sociologist Linda J. Waite, journalist Maggie Gallagher, and a number of other scholars, this book’s findings dramatically contradict the anti-marriage myths that have become the common sense of most Americans. Today a broad consensus holds that marriage is a bad deal for women, that divorce is better for childr...
