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Drosophila as a Model Organism for Ageing Studies
Many books on ageing attempt to cover the whole field of gerontology. However, since gerontology is now such a diversified and rapidly expanding subject, the results of such attempts tend to be either incomprehensible compendia or encyc10pedias of disheartening size. The present book aims to be both more modest and more ambitious. It focuses on a single object (Drosophila), but attempts to off er a synthesis of all the gerontological work that has been done on it. It also aims to show the extent to which this work has led to an understanding of the biological phenomena of ageing, longevity, senescence and death in higher organisms, inc1uding man. Finally it attempts, on the basis of current knowledge, to mark out the paths that the next generation of researchers will most probably follow. Drosophila has been used as a model organism to advance our basic knowledge of the fundamentals of genetics and gerontology. It may be noted that the pioneering work on the genetics of ageing, which used Drosophila, began very early in this century, within the first decade of the rediscovery of Mendel's laws.
Aging
Aging inspired a large number of theories trying to rationalize the aging process common to all living beings. In this publication the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are reviewed. Furthermore theoretical and experimental evidence of the most important theoretical elements based on Darwinian evolution, cellular aging, role of cell membranes, free radicals and oxidative processes, receptor-mediated reactions, the extracellular matrix and immune functions as well as the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are discussed. These presentations of theories and related experimental facts give a global overview of up to date concepts of the biology of the aging process and are of essential reading not only for specialists in this field but also for practitioners of scientific, medical, social and experimental sciences.
Explaining Health Across the Sciences
This edited volume aims to better understand the multifaceted phenomenon we call health. Going beyond simple views of health as the absence of disease or as complete well-being, this book unites scientists and philosophers. The contributions clarify the links between health and adaptation, robustness, resilience, or dynamic homeostasis, and discuss how to achieve health and healthy aging through practices such as hormesis. The book is divided into three parts and a conclusion: the first part explains health from within specific disciplines, the second part explores health from the perspective of a bodily part, system, function, or even the environment in which organisms live, and the final p...
Artificial Intelligence for Healthy Longevity
This book reviews the state-of-the-art efforts to apply machine learning and AI methods for healthy aging and longevity research, diagnosis, and therapy development. The book examines the methods of machine learning and their application in the analysis of big medical data, medical images, the creation of algorithms for assessing biological age, and effectiveness of geroprotective medications. The promises and challenges of using AI to help achieve healthy longevity for the population are manifold. This volume, written by world-leading experts working at the intersection of AI and aging, provides a unique synergy of these two highly prominent fields and aims to create a balanced and comprehensive overview of the application methodology that can help achieve healthy longevity for the population. The book is accessible and valuable for specialists in AI and longevity research, as well as a wide readership, including gerontologists, geriatricians, medical specialists, and students from diverse fields, basic scientists, public and private research entities, and policy makers interested in potential intervention in degenerative aging processes using advanced computational tools.
Sleep and Clocks in Aging and Longevity
This edited volume focuses on the interplay between sleep and circadian rhythms with health, aging and longevity. Sleep is absolutely important for human health and survival, as insufficient sleep is associated with a plethora of conditions, including the poor quality of life, onset of several diseases, and premature death. The sleep–wake cycle is an evolutionary conserved neurobiological phenomenon, and is a prominent manifestation of the biological clocks localised in the suprachiasmatic nucleus (SCN). Understanding bidirectional relationship between sleep and circadian rhythms is of utmost importance and urgency, especially in the context of modern lifestyle where sleep is often out of ...
Origins as a Paradigm in the Sciences and in the Humanities
In this volume, the assumption that origins can be defined as a hermeneutic paradigm in the humanities and in the sciences is explored in relation to specific theoretical frameworks and research methodologies. By investigating how origins have been conceptualised in different domains of knowledge - biology, primatology, psychology, linguistics, history of science, critical theory, classical studies, philology, literary criticism, strategy and accounting - a double movement has been generated: towards the very core of each discipline and beyond disciplinary boundaries. Which are the most productive theories and methods each discipline has elaborated for investigating origins? Can they become trans-disciplinary? Which synergic enquiries can be devised in order to expand and share knowledge? Explaining how and why various disciplines have responded to such questions involves delving into their histories and cultural ideologies in order to verify whether the topic of origins can function as a powerful connector between scientific and humanistic territories.
Healthy Longevity and Immune System
This book presents studies of the main conditions that affect health and well-being of old people. Considering the present scenario of COVID-19, the effects of this viral infection on individuals older than 65 years are also discussed. The content enables professionals of health and government for the present and future actions in this important area. Readers go through the changes occurring in organs and tissues that can interfere with susceptibility to infections, low response to vaccines, cancer, and loss of cognition during the aging process. A discussion of the central role played by the immune system in the age-related diseases and how the immunity can be impaired during the ageing process is presented. Possibilities to circumvent these conditions via healthy habits in diet, physical exercise, and new pharmacological interventions are part of the content. This book discusses how human healthy longevity is dependent, at least in part, of a functional immune system. Chapters were written for researchers in the field of aging and is especially suited for those interested in the study of immunosenescence and inflammaging affecting the health of old individuals.
Modulating Aging and Longevity
After decades of systematic collection of data describing age-related changes in organisms, organs, tissues, cells and macromolecules, biogerontologists are now in a position to construct general principles of ageing and explore various possibilities of intervention using rational approaches. While not giving serious consideration to the claims made by charlatans, it cannot be ignored that several researchers are making genuine attempts to test and develop various means of intervention for the prevention and treatment of age-related diseases, for regaining the functional abilities and for prolonging the lifespan of experimental organisms. This book provides the most up-to-date information and a critical evaluation of a variety of approaches being tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress. The goal of research on ageing is not to increase human longevity regardless of the consequences, but to increase active longevity free from disability and functional dependence.
