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Exercise as a Countermeasure to Human Aging
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Protein Kinases
Proteins are the work horses of the cell. As regulators of protein function, protein kinases are involved in the control of cellular functions via intricate signalling pathways, allowing for fine tuning of physiological functions. This book is a collaborative effort, with contribution from experts in their respective fields, reflecting the spirit of collaboration - across disciplines and borders - that exists in modern science. Here, we review the existing literature and, on occasions, provide novel data on the function of protein kinases in various systems. We also discuss the implications of these findings in the context of disease, treatment, and drug development.
Diuretics
Diuretics are drugs that increase urine water and salt excretion, and for that reason they are widely used for treating arterial hypertension, and edematous states such as decompensated cardiac failure, cirrhosis, and nephropathy. In this book, the authors present current research in the study of the pharmacology, therapeutic uses and adverse side effects of diuretics. Topics include the aquaretic effect of vasopressin V2 receptor antagonists; basic principles of diuretic therapy; predictors to blood pressure response and the adverse side effects of thiazide diuretics; diuretic therapy in heart failure; diuretics as antiepileptics; and potent diuretics and potassium sparing agents.
Uremic Toxins
The present book contains the Proceedings of a two day Symposium on Uremic Toxins organized at the University of Ghent in Belgium. A series of guest lectures, free communications and posters have been presented. An international audience of 163 scientists from 16 nationalities listened to and discussed extensively a spectrum of topics brought forward by colleagues and researchers who worked for many years in the field of Uremic Toxins. There is a striking contrast between all the new dialysis strategies available in the work to "clean" the uremic patients and the almost non-progression of our knowledge on uremic toxins in the past decade. In this sense the symposium was felt by all participants as a new start for the research in the biochemical field of the definition of uremia. If the present volume would stimulate new work in this field in order to define uremia, or identify the uremic toxins, the purpose of the organizers would be maximally fulfilled.
Naples Lab
Perhaps because it was the last stop on the Grand Tour, surely because its beauty is highly seductive, one cannot remain indifferent to the millennial city of Naples. Naples, where students and professors from urbanism, architecture, architectural engineering and design from Northern and Southern European universities met twice a year between 2013 and 2018 to capture the qualities of Naples's specific territory and respond to the contemporary situation. The first part of the book relates to lectures given by local researchers. The second part concerns the tentative designs and resilience in the face of modern challenges. Again, the proposals at Naples’s persistence in hosting Europe’s historical richness through time, and its great diversity of people and uses throughout space.
Enzyme Inhibition and Bioapplications
Enzyme Inhibition and Bioapplications is a concise book on applied methods of enzymes used in drug testing. The present volume will serve the purpose of applied drug evaluation methods in research projects, as well as relatively experienced enzyme scientists who might wish to develop their experiments further. Chapters are arranged in the order of basic concepts of enzyme inhibition and physiological basis of cytochromes followed by new concepts of applied drug therapy; reliability analysis; and new enzyme applications from mechanistic point of view.
The Macroeconomics of Populism in Latin America
Again and again, Latin America has seen the populist scenario played to an unfortunate end. Upon gaining power, populist governments attempt to revive the economy through massive spending. After an initial recovery, inflation reemerges and the government responds with wage an price controls. Shortages, overvaluation, burgeoning deficits, and capital flight soon precipitate economic crisis, with a subsequent collapse of the populist regime. The lessons of this experience are especially valuable for countries in Eastern Europe, as they face major political and economic decisions. Economists and political scientists from the United States and Latin America detail in this volume how and why such...
Pathophysiology of Heart Failure
Pathophysiology of Heart Failure brings together leading basic scientists and clinicians, presenting new approaches to this complex problem, involving cardiomyopathic processes and ischemia perfusion injury. The result is a synthesis of state-of-the-art information on molecular biology, cellular physiology and structure-function relationships in the cardiovascular system. The role which excess intracellular calcium plays in the genesis of cardiac dysfunction is described as a fundamental mechanism underlying heart failure; one which may lead to improved prevention and treatment. Audience: Clinical and experimental cardiologists will find the book a helpful source of ideas and inspiration.
