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Horizontal Gene Transfer Mediated Multidrug Resistance: A Global Crisis, 2nd Edition
Throughout history, human life has been seriously threatened by bacterial infectious diseases. After the discovery of antibiotics, humanity thought it had won the fight against infectious bacteria. However, considering the rapid evolution of bacterial multidrug resistance and exhausted pipeline of antibiotics for fighting bacterial infectious diseases, we are approaching the ‘post-antibiotic’ era. Unlike eukaryote, bacteria are proficient in exchanging their genetic materials with others by means of horizontal gene transfer (HGT). As a vehicle for antibiotic resistance gene (ARG), plasmid is self-replicable and transferable in a wide range of host bacteria. Moreover, ways of HGT-mediated...
Surveying Antimicrobial Resistance: The New Complexity of the Problem
In January of 2015, under the 1st International Caparica Conference in Antibiotic Resistance, a Research Topic entitled: “Surveying Antimicrobial Resistance: Approaches, Issues, and Challenges to overcome”, was published (http://journal.frontiersin.org/researchtopic/3763/surveying-antimicrobial-resistanceapproaches- issues-and-challenges-to-overcome). The problem of antimicrobial resistance (AMR), caused by excessive and inappropriate use of antibiotics, is a public health issue that concerns us all. The introduction of penicillin in the 1940s, the start of the antibiotics era, has been recognized as one of the greatest advances in therapeutic medicine. However, according to the World He...
Emerging Strategies in Combatting and Managing Bacterial Biofilms
Biofilm formation is a survival strategy for many microorganisms. Within biofilms, microorganisms live in multicellular communities enclosed in a protective matrix that enables them to survive harsh conditions and resist conventional treatments. The ability of biofilm-forming microorganisms to inhabit different biotic and abiotic surfaces facilitates their widespread existence in different environments including health care facilities, water systems, ships, and even living hosts. Hence, this microbial phenotype became a major concern in various sectors including public health, medicine, and industry. The challenge imparted by the detrimental effects of biofilms has sparked the interest of ma...
Diet and Cancer
The fifth of the annual research conferences of the American Institute for Cancer Research was held September l-2, 1994, at the L'Enfant Plaza Hotel in Washington, DC. Appropriately, in view of current directions in research, the theme was "Diet and Cancer: Molecular Mechanisms of Interactions". This proceedings volume contains chapters from the platform presentations and abstracts from the poster session held on the end of the first day. The subtopics for the tl;rree sessions held were "Retinoids, Vitamins A and Din Cancer Prevention and Therapy," "Choline and Lipids: Signal Transduction, Gene Expression and Growth Regulation," and "Dietary Factors and Regulation of Oncogenes, Growth and Di...
Microbial Genome Methods
Learn to apply powerful molecular biology and genetics techniques to your microbial research with this easy-to-understand, practical guide. Microbial Genome Methods distills complex experimental procedures into fundamental techniques that can be readily adapted to your own research. In addition, this book provides background information specifically relevant to microbial research, as well as descriptions of expected results. The book is divided into two sections. Section one covers eukaryotic microbes, with emphasis on the yeast Saccharomyces cerevisiae. Section two covers prokaryotic microbes, focusing on Escherichia coli, and other important bacteria. These microbes were selected because they are widely studied and understood, but all information can be easily applied to the microbe you are investigating. Chapters are written by nationally and internationally recognized research scientists currently active in this field. Don't miss out on the tremendous boost these research techniques can give your work.
