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Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: a German Single-center Analysis
Abstract: Molecular precision oncology faces two major challenges: first, to identify relevant and actionable molecular variants in a rapidly changing field and second, to provide access to a broad patient population. Here, we report a four-year experience of the Molecular Tumor Board (MTB) of the Comprehensive Cancer Center Freiburg (Germany) including workflows and process optimizations. This retrospective single-center study includes data on 488 patients enrolled in the MTB from February 2015 through December 2018. Recommendations include individual molecular diagnostics, molecular stratified therapies, assessment of treatment adherence and patient outcomes including overall survival. The...
Proton and Carbon Ion Therapy
Proton and Carbon Ion Therapy is an up-to-date guide to using proton and carbon ion therapy in modern cancer treatment. The book covers the physics and radiobiology basics of proton and ion beams, dosimetry methods and radiation measurements, and treatment delivery systems. It gives practical guidance on patient setup, target localization, and treatment planning for clinical proton and carbon ion therapy. The text also offers detailed reports on the treatment of pediatric cancers, lymphomas, and various other cancers. After an overview, the book focuses on the fundamental aspects of proton and carbon ion therapy equipment, including accelerators, gantries, and delivery systems. It then discu...
Kindergarten Chats and Other Writings
A reprint of the definitive 1918 edition, this bold, thought-provoking volume by one of America's most influential architects features dialogs, or "chats," about architecture, art, education, and life in general. 17 illustrations.
Functional Equations and Inequalities
This volume provides an extensive study of some of the most important topics of current interest in functional equations and inequalities. Subjects dealt with include: a Pythagorean functional equation, a functional definition of trigonometric functions, the functional equation of the square root spiral, a conditional Cauchy functional equation, an iterative functional equation, the Hille-type functional equation, the polynomial-like iterative functional equation, distribution of zeros and inequalities for zeros of algebraic polynomials, a qualitative study of Lobachevsky's complex functional equation, functional inequalities in special classes of functions, replicativity and function spaces...
Surgical Treatment of Pancreatic Ductal Adenocarcinoma
This book contains the art and science in current standards of surgical treatment of pancreatic ductal adenocarcinoma. It explains the clinical role of surgical resection during multimodal treatment in patients with pancreatic ductal adenocarcinoma, novel surgical techniques including extended pancreatectomy and minimally invasive surgery, risk of cancer in IPMN, and the clinical importance of liquid biopsy.
Applications of GNSS Reflectometry for Earth Observation
Global Navigation Satellite System-Reflectometry (GNSS-R) has proven an effective and very valuable technique that has helped the scientific community to better understand Earth processes. Measuring the forward scattering that occurs when the Global Positioning System (GPS) signals reflect off the surface of the Earth has enabled multiple studies of the ocean, the cryosphere, and the land geophysical phenomena, allowing a better characterization and increasing the global knowledge of our planet. This book brings together a variety of the most up-to-date research on the GNSS-R field, covering multiple and very innovative applications.
