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Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: a German Single-center Analysis
Abstract: Molecular precision oncology faces two major challenges: first, to identify relevant and actionable molecular variants in a rapidly changing field and second, to provide access to a broad patient population. Here, we report a four-year experience of the Molecular Tumor Board (MTB) of the Comprehensive Cancer Center Freiburg (Germany) including workflows and process optimizations. This retrospective single-center study includes data on 488 patients enrolled in the MTB from February 2015 through December 2018. Recommendations include individual molecular diagnostics, molecular stratified therapies, assessment of treatment adherence and patient outcomes including overall survival. The...
Personalized Clinical Decision Making Through Implementation of a Molecular Tumor Board: a German Single-center Experience
Abstract: Purpose Dramatic advances in our understanding of the molecular pathophysiology of cancer, along with a rapidly expanding portfolio of molecular targeted drugs, have led to a paradigm shift toward personalized, biomarker-driven cancer treatment. Here, we report the 2-year experience of the Comprehensive Cancer Center Freiburg Molecular Tumor Board (MTB), one of the first interdisciplinary molecular tumor conferences established in Europe. The role of the MTB is to recommend personalized therapy for patients with cancer beyond standard-of-care treatment. Methods This retrospective case series includes 198 patients discussed from March 2015 through February 2017. The MTB guided indiv...
The Journal of Cell Biology
No. 2, pt. 2 of November issue each year from v. 19-47; 1963-70 and v. 55- 1972- contain the Abstracts of papers presented at the annual meeting of the American Society for Cell Biology, 3d-10th; 1963-70 and 12th- 1972- .
Das Erziehungswesen im späten 18. Jahrhundert am Beispiel des Romans "Anton Reiser" von Karl Phillip Moritz
Studienarbeit aus dem Jahr 2010 im Fachbereich Pädagogik - Geschichte der Pädagogik, Note: 2,5, Universität zu Köln (Erziehungswissenschaftliches Institut Humanwissenschaftliche Fakultät), Veranstaltung: Pädagogik und Gesellschaft, Sprache: Deutsch, Abstract: In dieser Hausarbeit beschäftige ich mich mit dem autobiographischen Roman „Anton Reiser“ von Karl Phillip Moritz. Ich habe mich mit den wesentlichen Aussagen des Buches beschäftigt, die meiner Meinung nach die Missstände und Unfähigkeit des Erziehungswesens im späten 18. Jahrhundert deutlich machen. Gleichzeitig möchte ich damit aufzeigen, wie notwendig es war, die Erkenntnisse der Aufklärungszeit auch auf das Erziehungswesen anzuwenden. Dazu werde ich zunächst die Gesellschaftsstrukturen und wirtschaftlichen Verhältnisse der Zeit Anton Reisers beschreiben und ansatzweise die Grundzüge der Aufklärung in der Pädagogik zu skizzieren. Daran an schließt die Analyse des Romans und die Erläuterung des damaligen Erziehungswesens und seiner Mängel.
Explainable Artificial Intelligence
This three-volume set constitutes the refereed proceedings of the First World Conference on Explainable Artificial Intelligence, xAI 2023, held in Lisbon, Portugal, in July 2023. The 94 papers presented were thoroughly reviewed and selected from the 220 qualified submissions. They are organized in the following topical sections: Part I: Interdisciplinary perspectives, approaches and strategies for xAI; Model-agnostic explanations, methods and techniques for xAI, Causality and Explainable AI; Explainable AI in Finance, cybersecurity, health-care and biomedicine. Part II: Surveys, benchmarks, visual representations and applications for xAI; xAI for decision-making and human-AI collaboration, for Machine Learning on Graphs with Ontologies and Graph Neural Networks; Actionable eXplainable AI, Semantics and explainability, and Explanations for Advice-Giving Systems. Part III: xAI for time series and Natural Language Processing; Human-centered explanations and xAI for Trustworthy and Responsible AI; Explainable and Interpretable AI with Argumentation, Representational Learning and concept extraction for xAI.
Triad Berlin
Triad: linking culture, media and environment. This Berlin-based design agency has won awards for its planet M project at Expo2000 in Hanover, and its Happy Ending event at Expo02 was one of the great successes of that fair. Within a decade, Triad has made its mark on the national and international design world, thanks to a truly interdisciplinary approach to design that ranges across both cultural and commercial projects and clients.
Goethe Yearbook 29
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