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Donor Site Morbidity After Computer Assisted Surgical Reconstruction of the Mandible Using Deep Circumflex Iliac Artery Grafts: a Cross Sectional Study
Abstract: Background Computer Assisted Design and Computer Assisted Manufacturing (CAD/CAM) have revolutionized oncologic surgery of the head and neck. A multitude of benefits of this technique has been described, but there are only few reports of donor site comorbidity following CAD/CAM surgery. Methods This study investigated comorbidity of the hip following deep circumflex iliac artery (DCIA) graft raising using CAD/CAM techniques. A cross-sectional examination was performed to determine range of motion, muscle strength and nerve disturbances. Furthermore, correlations between graft volume and skin incision length with postoperative donor site morbidity were assessed using Spearman's rank...
Doing Business in 2004
A co-publication of the World Bank, International Finance Corporation and Oxford University Press
Stimulated Raman Histology for Histological Evaluation of Oral Squamous Cell Carcinoma
Abstract: Objectives To investigate whether in patients undergoing surgery for oral squamous cell carcinoma, stimulated Raman histology (SRH), in comparison with H&E-stained frozen sections, can provide accurate diagnoses regarding neoplastic tissue and sub-classification of non-neoplastic tissues. Materials and methods SRH, a technology based on Raman scattering, was applied to generate digital histopathologic images of 80 tissue samples obtained from 8 oral squamous cell carcinoma (OSCC) patients. Conventional H&E-stained frozen sections were then obtained from all 80 samples. All images/sections (SRH and H&E) were analyzed for squamous cell carcinoma, normal mucosa, connective tissue, mus...
"You cannot imagine what it is like in America."
The United States. The land of unimagined opportunities. A place of longing for many Germans for decades. This book describes why people from the Bavarian Forest emigrated to the United States from 1841 to 1931. Diverse documents from German and American archives, historical records, and maps, assembled over many years, are augmented by a wealth of authentic, fascinating letters, photographs, and diary entries from the emigrating families. Vivid conversations and meetings with present-day descendants bring the story full circle! You will experience · the hard life in the Bavarian Forest villages · the hopeful letters from America · the attempts of the authorities to thwart emigration plans · the arduous and often painful preparations for the trip · the adventure-filled, transatlantic crossing 'tween deck · the critical examinations on Ellis Island and · the difficult new beginning in the New World This book forms the basis of the exhibits in the "Born in Schiefweg" Emigration Museum in the Bavarian Forest. It also found its way into the permanent exhibition of the German Emigration Center in Bremerhaven, Germany.
Analysis of the Accuracy of Computer-assisted DCIA Flap Mandibular Reconstruction Applying a Novel Approach Based on Geometric Morphometrics
Abstract: Background This study evaluated the accuracy of computer-assisted surgery (CAS)-driven DCIA (deep circumflex iliac artery) flap mandibular reconstruction by traditional morphometric methods and geometric morphometric methods (GMM). Methods Reconstruction accuracy was evaluated by measuring distances and angles between bilateral anatomical landmarks. Additionally, the average length of displacements vectors between landmarks was computed to evaluate factors assumed to influence reconstruction accuracy. Principal component analysis (PCA) was applied to unveil main modes of dislocation. Results High reconstruction accuracy could be demonstrated for a sample consisting of 26 patients. The effect of the number of segments and length of defect on reconstruction accuracy were close to the commonly used significance threshold (p = 0.062/0.060). PCA demonstrated displacement to result mainly from sagittal and transversal shifts. Conclusions CAS is a viable approach to achieve high accuracy in mandibular reconstruction and GMM can facilitate the evaluation of factors influencing reconstruction accuracy and unveil main modes of dislocation in this context
Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: a German Single-center Analysis
Abstract: Molecular precision oncology faces two major challenges: first, to identify relevant and actionable molecular variants in a rapidly changing field and second, to provide access to a broad patient population. Here, we report a four-year experience of the Molecular Tumor Board (MTB) of the Comprehensive Cancer Center Freiburg (Germany) including workflows and process optimizations. This retrospective single-center study includes data on 488 patients enrolled in the MTB from February 2015 through December 2018. Recommendations include individual molecular diagnostics, molecular stratified therapies, assessment of treatment adherence and patient outcomes including overall survival. The...
A Drug Holiday Reduces the Frequency and Severity of Medication-related Osteonecrosis of the Jaw in a Minipig Model
Abstract: Treatment of medication-related osteonecrosis of the jaw (MRONJ) is challenging and no clear consensus has been achieved. This study investigated preventive measures recommended for tooth extractions under antiresorptive (AR) treatment and the role of discontinuation of AR therapy to avoid the onset of MRONJ in a minipig model. Thirty-six Göttingen minipigs were divided into four groups. Group 1 (negative control): tooth extractions but no zoledronate (ZOL). Group 2 (positive control): weekly ZOL infusions for 12 weeks followed by tooth extractions without wound management followed by 8 weeks of ZOL treatment. Group 3: weekly ZOL infusions for 12 weeks followed by tooth extraction...
